Description

Cdk2/9 Inhibitor CAS NO 507487-89-0 is a potent and selective small molecule inhibitor targeting cyclin-dependent kinases 2 and 9, key regulators of the cell cycle and transcription. This compound is a critical research tool for studying cell proliferation, apoptosis, and transcriptional control in various disease models, particularly oncology. It is essential for pharmaceutical R&D, academic research, and biotechnology companies focused on developing novel therapeutics for cancer and other proliferative disorders.

Application

• Biochemical Research: Used as a selective inhibitor to study the specific roles and signaling pathways of CDK2 and CDK9 in vitro.
• Cancer Research: A vital tool for investigating cell cycle arrest, inducing apoptosis, and evaluating anti-proliferative effects in various cancer cell lines.
• Drug Discovery & Development: Serves as a reference compound or lead molecule in high-throughput screening and structure-activity relationship (SAR) studies for novel kinase inhibitors.
• Mechanistic Studies: Employed to elucidate the mechanisms of transcriptional regulation, particularly the control of RNA polymerase II-dependent transcription.
• Pharmacology: Used in preclinical studies to validate CDK2/9 as therapeutic targets and to assess efficacy in animal models of disease.
• Academic Research: Fundamental for university and institutional labs exploring basic cell biology, oncology, and kinase biology.

Basic Information

Product Name	Cdk2/9 Inhibitor
CAS No.	507487-89-0
Molecular Formula	C₂₁H₂₀N₈O
Molecular Weight	400.44 g/mol
Synonyms	CDK2/9 Inhibitor; 507487-89-0; 5-((4-Ethylpiperazin-1-yl)methyl)-N-(3-(1H-indol-4-yl)-1H-pyrazolo[3,4-b]pyridin-5-yl)pyrimidin-2-amine; AT-7519; AT7519; CDK Inhibitor AT7519; AT-7519 HCl (if applicable); Cyclin-Dependent Kinase Inhibitor AT7519
EINECS	Contact for details

Quality Control

Our Cdk2/9 Inhibitor is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under inert conditions for long-term stability. The product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular weight
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.