Description

Tpca-1 CAS NO 507475-17-4 is a potent and selective inhibitor of the p38α mitogen-activated protein kinase (MAPK), a key signaling protein involved in cellular stress and inflammatory responses. This compound is a critical research tool for investigating the p38 MAPK pathway's role in disease mechanisms, particularly inflammation, autoimmune disorders, and certain cancers. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies engaged in drug discovery and preclinical studies.

Application

• Biochemical Research: Used as a selective p38α MAPK inhibitor to study kinase signaling pathways, enzyme kinetics, and cellular response mechanisms in vitro.
• Drug Discovery & Development: Serves as a reference standard and a lead compound in the development of novel anti-inflammatory and immunomodulatory therapeutics.
• Cell Biology Studies: Employed to modulate p38 activity in cell cultures to understand its role in apoptosis, cytokine production, and cellular differentiation.
• Inflammation & Immunology Research: A vital tool for modeling inflammatory diseases and screening potential therapeutic agents that target the p38 MAPK pathway.
• Oncology Research: Investigated for its potential effects on cancer cell proliferation and survival where p38 signaling is implicated.

Basic Information

Product Name	Tpca-1
CAS No.	507475-17-4
Molecular Formula	C16H14N4O2S
Molecular Weight	326.37 g/mol
Synonyms	4-(5-(4-Fluorophenyl)-2-methylsulfanyl-4H-imidazol-4-yl)pyridine; Tpca 1; Tpca1; 4-[5-(4-Fluorophenyl)-2-(methylthio)-4-imidazolyl]pyridine; 4-[5-(4-Fluorophenyl)-2-(methylsulfanyl)-1H-imidazol-4-yl]pyridine; BML-EI305; EI-305; p38α MAPK Inhibitor Tpca-1
EINECS	Contact for details

Quality Control

Our Tpca-1 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and safety parameters is provided with every shipment to ensure it meets the stringent requirements of research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.