Description

2-Chloro-5-(Trifluoromethyl)-3-Pyridinecarboxylic Acid is a high-value, multi-functional pyridine derivative that serves as a critical building block in advanced chemical synthesis. Its molecular structure, featuring both chloro and trifluoromethyl substituents, makes it an essential intermediate for creating compounds with tailored biological activity and material properties. This product is primarily utilized by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting central nervous system (CNS) and metabolic diseases.
• Agrochemical Synthesis: Serves as a core building block for novel herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing properties of the trifluoromethyl group.
• Ligand and Catalyst Precursor: Used in the preparation of specialized ligands for transition metal catalysis and in the synthesis of organocatalysts.
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and organic electronic materials due to its aromatic and electron-withdrawing characteristics.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in bespoke synthesis projects and scale-up campaigns.

Basic Information

Product Name	2-Chloro-5-(Trifluoromethyl)-3-Pyridinecarboxylic Acid
CAS No.	505084-59-3
Molecular Formula	C7H3ClF3NO2
Molecular Weight	225.55 g/mol
Synonyms	2-Chloro-5-(trifluoromethyl)nicotinic acid; 3-Pyridinecarboxylic acid, 2-chloro-5-(trifluoromethyl)-; 2-Chloro-5-trifluoromethylpyridine-3-carboxylic acid; 2-Chloro-5-(trifluoromethyl)pyridine-3-carboxylic acid; 5-(Trifluoromethyl)-2-chloronicotinic acid; 2-Chloro-α,α,α-trifluoro-5-pyridinecarboxylic acid
EINECS	Contact for details

Quality Control

Our production of 2-Chloro-5-(Trifluoromethyl)-3-Pyridinecarboxylic Acid adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high purity. Quality is verified through modern analytical techniques including HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment, supporting regulatory filings and quality assurance protocols in cGMP environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); the container must be kept tightly sealed to prevent absorption of atmospheric moisture, which can affect purity and stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.