Description

10-Hydroxy-9-[(Dimethylamino)Methyl]-5-Ethoxy-(20S,5Rs)-Camptothecin is a high-purity synthetic derivative of the potent topoisomerase I inhibitor, camptothecin. This compound is engineered for advanced pharmaceutical research and development, offering a critical scaffold for creating novel anti-cancer therapeutics. It is essential for medicinal chemists and research institutions focused on oncology drug discovery, particularly in the synthesis and evaluation of next-generation chemotherapeutic agents.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel camptothecin-based anti-cancer drugs.
• Oncology Research: Used as a reference standard and active compound in biochemical assays to study topoisomerase I inhibition mechanisms.
• Medicinal Chemistry: Serves as a core structure for structural-activity relationship (SAR) studies to optimize potency and reduce toxicity.
• Preclinical Development: Employed in the formulation and efficacy testing of new chemotherapeutic candidates in laboratory models.
• API Synthesis: Utilized in the development and scale-up processes for potential Active Pharmaceutical Ingredients (APIs).

Basic Information

Product Name	10-Hydroxy-9-[(Dimethylamino)Methyl]-5-Ethoxy-(20S,5Rs)-Camptothecin
CAS No.	504413-76-7
Molecular Formula	C25H27N3O5
Molecular Weight	449.50 g/mol
Synonyms	10-Hydroxy-9-[(dimethylamino)methyl]-5-ethoxy-(20S,5Rs)-camptothecin; 5-Ethoxy-10-hydroxy-9-[(dimethylamino)methyl]-(20S)-camptothecin; (20S)-10-Hydroxy-9-[(dimethylamino)methyl]-5-ethoxycamptothecin; Camptothecin derivative 504413-76-7; 9-(Dimethylaminomethyl)-10-hydroxy-5-ethoxycamptothecin; (S)-10-Hydroxy-9-((dimethylamino)methyl)-5-ethoxycamptothecin; 5-Ethoxy-10-hydroxy-9-(N,N-dimethylaminomethyl)camptothecin
EINECS	Contact for details

Quality Control

Our 10-Hydroxy-9-[(Dimethylamino)Methyl]-5-Ethoxy-(20S,5Rs)-Camptothecin is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to cGMP guidelines where applicable to support our clients' development needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the certificate of analysis. This compound is light-sensitive (store away from light) and hygroscopic (moisture-sensitive); therefore, containers should be kept in a dry environment and desiccated if necessary.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.