Description

Ku57788 (NU7441) is a potent and selective small-molecule inhibitor of the DNA-dependent protein kinase (DNA-PK), a key enzyme in the non-homologous end joining (NHEJ) pathway of DNA double-strand break repair. This compound matters because it serves as a critical research tool for investigating DNA damage response mechanisms and for sensitizing cancer cells to DNA-damaging therapies like radiation and certain chemotherapeutics. It is primarily needed by researchers and pharmaceutical developers in the fields of oncology, radiobiology, and molecular biology for preclinical studies and drug discovery programs.

Application

• Oncology Research: Used to study DNA repair pathways and to potentiate the effects of ionizing radiation and DNA-damaging agents in cancer cell lines.
• Drug Discovery: Serves as a reference compound and pharmacological tool in screening assays to identify novel DNA-PK inhibitors or combination therapies.
• Radiobiology Studies: Employed to investigate cellular responses to radiation and the role of NHEJ in maintaining genomic stability.
• Mechanistic Studies: Utilized in biochemical and cellular assays to dissect the specific functions of DNA-PK in signal transduction and DNA repair.
• Combination Therapy Research: Explored in preclinical models to enhance the efficacy of radiotherapy and chemotherapeutic agents like topoisomerase II inhibitors.
• Cell Cycle & Apoptosis Analysis: Applied in studies to understand cell fate decisions following DNA damage, including checkpoint activation and programmed cell death.

Basic Information

Product Name	Ku57788 (NU7441)
CAS No.	503468-95-9
Molecular Formula	C₂₁H₂₂N₈O₂
Molecular Weight	418.45 g/mol
Synonyms	NU7441; Ku-57788; 2-(Morpholin-4-yl)-benzo[h]chromen-4-one; 8-Dibenzofuranyl-2-(4-morpholinyl)-4H-1-benzopyran-4-one; DNA-PK Inhibitor, NU 7441; DNA-PK Inhibitor II; DNA-PK Inhibitor Ku-57788
EINECS	Contact for details

Quality Control

Our Ku57788 (NU7441) is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and NMR for structural confirmation, to ensure high chemical integrity and batch-to-batch consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	Off-white to yellow solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.