Description

n-Debenzoyl-n-[(3E)-Hex-3-Enoyl]Paclitaxel is a key synthetic intermediate in the production of paclitaxel and related taxane derivatives, which are critical chemotherapeutic agents. This compound is essential for pharmaceutical R&D and manufacturing, enabling the development of novel drug candidates and biosynthetic pathways. It is primarily utilized by pharmaceutical companies, research institutions, and fine chemical manufacturers specializing in oncology drug development and advanced organic synthesis.

Application

• Pharmaceutical Intermediate: A crucial building block in the semi-synthesis and total synthesis of Paclitaxel (Taxol®) and its analogs.
• Oncology Research: Used in the research and development of next-generation taxane-based chemotherapeutic agents to improve efficacy and reduce side effects.
• Process Chemistry: Serves as a strategic intermediate in scaling up the manufacturing process for complex anti-cancer drugs.
• Bioconjugation Studies: Employed in the development of antibody-drug conjugates (ADCs) and other targeted drug delivery systems.
• Structure-Activity Relationship (SAR) Studies: Fundamental for medicinal chemistry programs aimed at understanding and optimizing the biological activity of taxane scaffolds.
• Reference Standard: Used as a high-purity analytical standard for quality control and regulatory submissions in pharmaceutical production.

Basic Information

Product Name	n-Debenzoyl-n-[(3E)-Hex-3-Enoyl]Paclitaxel
CAS No.	502626-06-4
Molecular Formula	C39H49NO13
Molecular Weight	739.81 g/mol
Synonyms	7-Deoxy-13-oxo-10-deacetylpaclitaxel; 10-Deacetyl-7-deoxy-13-oxopaclitaxel; (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-4,6,9,11,12a-pentahydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benz[1,2-b]oxet-2-yl (3E)-hex-3-enoate; Paclitaxel Impurity; Taxane Intermediate
EINECS	Contact for details

Quality Control

Our n-Debenzoyl-n-[(3E)-Hex-3-Enoyl]Paclitaxel is manufactured under strict quality systems suitable for pharmaceutical research and development. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and MS. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with relevant guidelines. Specifications can be aligned with customer requirements for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.