Description

S3I-201 CAS NO 501919-59-1 is a high-purity, small molecule chemical compound widely recognized as a potent and selective inhibitor of STAT3 (Signal Transducer and Activator of Transcription 3). This compound matters significantly for researchers and developers targeting oncogenic signaling pathways, as it disrupts the STAT3-mediated transcription critical for tumor cell survival and proliferation. It is essential for pharmaceutical R&D, academic institutions, and biotechnology companies focused on developing novel cancer therapeutics and studying JAK-STAT signaling mechanisms.

Application

• Pharmaceutical Research & Development: A key tool compound for investigating the role of STAT3 in cancer biology, autoimmune diseases, and inflammatory conditions.
• Preclinical Drug Discovery: Used in in vitro and in vivo studies to validate STAT3 as a therapeutic target and to assess the efficacy of anti-cancer strategies.
• Biochemical Assays: Serves as a reference standard in high-throughput screening (HTS) campaigns to identify new STAT3 pathway modulators.
• Academic Research: Facilitates fundamental studies on cell signaling, transcription factor regulation, and apoptosis mechanisms.
• Oncology Research: Specifically applied in studies targeting STAT3-dependent cancers, including certain leukemias, lymphomas, and solid tumors.

Basic Information

Product Name	S3I-201
CAS No.	501919-59-1
Molecular Formula	C17H14N2O4S
Molecular Weight	342.37 g/mol
Synonyms	S3I-201; NSC 74859; 4-[(4-Bromophenyl)sulfonyl]phthalic anhydride; STAT3 Inhibitor S3I-201; 1,3-Dioxo-1,3-dihydro-2-benzofuran-5-carboxylic acid 4-bromophenyl ester; 5-[(4-Bromophenyl)sulfonyl]isobenzofuran-1,3-dione; 4-Bromo-N-(1,3-dioxo-1,3-dihydro-2-benzofuran-5-yl)benzenesulfonamide (related structure)
EINECS	Contact for details

Quality Control

Our S3I-201 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity confirmation, NMR and MS for structural identity, and residual solvent analysis. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with research-grade standards and support your regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.