Description

5,8-Difluoro-3,4-Dihydronaphthalen-1(2H)-One is a high-purity fluorinated organic building block, specifically a difluorinated tetralone derivative, essential for advanced synthetic chemistry. This compound matters because it serves as a critical precursor for synthesizing complex molecules, particularly in pharmaceutical research where the introduction of fluorine atoms can dramatically alter a compound's metabolic stability, bioavailability, and binding affinity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of fluorinated drug candidates, potentially in central nervous system (CNS) agents, kinase inhibitors, and anti-inflammatory compounds.
• Agrochemical Synthesis: Used in the research and production of novel fluorinated pesticides and herbicides, where fluorine enhances lipophilicity and environmental stability.
• Material Science Precursor: Employed in the synthesis of fluorinated organic semiconductors, liquid crystals, or advanced polymers for electronic and optical applications.
• Chemical Biology Probes: Serves as a scaffold for developing fluorinated probes and tags used in bioimaging and mechanistic studies.
• Catalysis & Ligand Development: Acts as a starting material for creating novel fluorinated ligands or catalysts in asymmetric synthesis.
• Academic & Contract Research: A valuable reagent for methodological studies in organic chemistry, particularly in cross-coupling and ring-forming reactions involving fluorinated arenes.

Basic Information

Product Name	5,8-Difluoro-3,4-Dihydronaphthalen-1(2H)-One
CAS No.	501373-03-1
Molecular Formula	C10H8F2O
Molecular Weight	182.17 g/mol
Synonyms	5,8-Difluoro-1-tetralone; 5,8-Difluoro-3,4-dihydro-1(2H)-naphthalenone; 5,8-Difluoro-α-tetralone; 1(2H)-Naphthalenone, 5,8-difluoro-3,4-dihydro-; 5,8-Difluoro-3,4-dihydronaphthalen-1-one; 5,8-Difluorotetralone
EINECS	Contact for details

Quality Control

Our 5,8-Difluoro-3,4-Dihydronaphthalen-1(2H)-One is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with the standards expected for cGMP and ISO 9001 compliant environments, supporting your regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.