Description

3-Fluoro-2-Methylbenzyl Bromide is a versatile and reactive organobromide building block, essential for advanced organic synthesis. Its value lies in the strategic positioning of the bromine and fluorine substituents on the benzyl ring, enabling efficient functionalization and the construction of complex molecular architectures. This compound is primarily needed by researchers and process chemists in the pharmaceutical, agrochemical, and material science industries for developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of fluorinated drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, anti-inflammatory agents, and kinase inhibitors.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the fluorine atom enhances biological activity, metabolic stability, and lipophilicity.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing specialized phosphine or nitrogen-based ligands used in asymmetric catalysis and transition metal complexes.
• Material Science Building Block: Employed in the synthesis of fluorinated liquid crystals, polymers, and organic electronic materials to modify their dielectric and optical properties.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Negishi, or Kumada couplings to form biaryl and other carbon-carbon bonds.
• Nucleophilic Substitution: The reactive benzyl bromide moiety allows for efficient alkylation of amines, thiols, and carboxylates to introduce the fluorinated benzyl group.

Basic Information

Product Name	3-Fluoro-2-Methylbenzyl Bromide
CAS No.	500912-14-1
Molecular Formula	C8H8BrF
Molecular Weight	203.05 g/mol
Synonyms	1-(Bromomethyl)-3-fluoro-2-methylbenzene; (3-Fluoro-2-methylphenyl)methyl Bromide; 2-Methyl-3-fluorobenzyl Bromide; α-Bromo-3-fluoro-2-methyltoluene; 3-Fluoro-2-methylbenzylbromide; 3-Fluoro-o-tolylmethyl Bromide; 2-Methyl-3-fluorobenzylbromide
EINECS	Contact for details

Quality Control

Our 3-Fluoro-2-Methylbenzyl Bromide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.