Description

Tr Antagonist 1 is a potent and selective small molecule inhibitor targeting the thyroid hormone receptor (TR). This compound is a critical research tool for investigating thyroid hormone signaling pathways and their role in metabolic regulation, development, and disease. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on endocrinology, metabolic disorders, and drug discovery.

Application

• Biochemical Research: Used as a selective antagonist to study the structure, function, and signaling mechanisms of thyroid hormone receptors (TRα and TRβ).
• Drug Discovery & Development: Serves as a lead compound or reference standard in screening assays and preclinical studies for novel TR-targeting therapeutics.
• Metabolic Disease Studies: Applied in cellular and animal models to investigate the role of TR in conditions such as obesity, hyperlipidemia, and non-alcoholic fatty liver disease (NAFLD).
• Cancer Research: Explored for its potential effects on thyroid hormone-dependent tumor growth and proliferation in various cancer cell lines.
• Academic & Institutional Labs: A key reagent for fundamental research in endocrinology, developmental biology, and gene expression regulation.
• High-Throughput Screening (HTS): Employed as a control or tool compound in automated assay systems to identify and validate new modulators of thyroid hormone activity.

Basic Information

Product Name	Tr Antagonist 1
CAS No.	500794-88-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Thyroid Hormone Receptor Antagonist 1; TR Antagonist-1; GC-1; 3,5-Dichloro-4-[(4-hydroxy-3-isopropylphenoxy)phenyl]acetic acid; Sobertirome; KB-141; KB141; KB 141
EINECS	Contact for details

Quality Control

Our Tr Antagonist 1 is produced under strict quality management protocols to ensure batch-to-batch consistency and reliability for research applications. All materials are accompanied by comprehensive analytical data. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request. We support research standards compliant with common pharmacopeial guidelines for reference compounds.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. For short-term use, the material may be stored at 2-8°C. The compound is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.