Description

4-Fluoro-3-Nitro-Benzenesulfonyl Fluoride is a versatile and highly reactive bifunctional aromatic building block, serving as a critical intermediate in advanced organic synthesis. Its dual functionality, featuring both a sulfonyl fluoride and a nitro group activated by an ortho-fluoro substituent, makes it an invaluable precursor for constructing complex molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of sulfonamide-based active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel sulfonamide drugs, including enzyme inhibitors and receptor antagonists.
• Agrochemical Synthesis: Building block for creating new-generation herbicides, fungicides, and pesticides with sulfonamide moieties.
• Chemical Biology & Proteomics: Used in activity-based protein profiling (ABPP) and the development of covalent inhibitors due to the reactivity of the sulfonyl fluoride group.
• Material Science: Intermediate for synthesizing specialty polymers, dyes, and liquid crystals.
• Cross-Coupling Reactions: Serves as an electrophilic partner in palladium-catalyzed cross-coupling reactions to introduce the sulfonyl fluoride functional group.
• Sulfur(VI) Fluoride Exchange (SuFEx) Click Chemistry: A high-quality reagent for constructing stable S-VI linkages, a cornerstone of modern click chemistry platforms.

Basic Information

Product Name	4-Fluoro-3-Nitro-Benzenesulfonyl Fluoride
CAS No.	500585-16-0
Molecular Formula	C6H3F2NO4S
Molecular Weight	223.16 g/mol
Synonyms	3-Nitro-4-fluorobenzenesulfonyl fluoride; 4-Fluoro-3-nitrobenzenesulfonyl fluoride; 1-Fluoro-2-nitro-4-(fluorosulfonyl)benzene; Benzenesulfonyl fluoride, 4-fluoro-3-nitro-; 4-Fluoro-3-nitrobenzene-1-sulfonyl fluoride
EINECS	Contact for details

Quality Control

Every batch of 4-Fluoro-3-Nitro-Benzenesulfonyl Fluoride is manufactured and tested under a strict quality management system. We ensure high purity and consistency through advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect product stability and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.