Description

2-Pyridinecarbonitrile, 3-Fluoro-4-Methyl-, 1-Oxide (9Ci) is a specialized heterocyclic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key precursor in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its unique fluorinated and oxidized pyridine structure enables precise molecular modifications. It is primarily needed by research and development chemists, process development scientists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for creating complex, high-value molecules.

Application

• Pharmaceutical Intermediate: A critical building block for synthesizing novel drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, leveraging its fluorinated pyridine core.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of advanced organic materials and functional polymers.
• Chemical Biology Probes: Useful for developing molecular probes and diagnostic agents due to its modifiable nitrile and N-oxide functional groups.

Basic Information

Item	Detail
Product Name	2-Pyridinecarbonitrile, 3-Fluoro-4-Methyl-, 1-Oxide (9Ci)
CAS No.	500306-05-8
Molecular Formula	C7H5FN2O
Molecular Weight	152.13 g/mol
Synonyms	3-Fluoro-4-methylpicolinonitrile 1-oxide; 3-Fluoro-4-methyl-2-pyridinecarbonitrile 1-oxide; 3-Fluoro-4-methylpyridine-2-carbonitrile N-oxide; 2-Cyano-3-fluoro-4-methylpyridine 1-oxide; 3-Fluoro-4-methyl-2-cyanopyridine N-oxide; 500306-05-8; 3-Fluoro-4-methylpicolinonitrile N-oxide
EINECS	Contact for details

Quality Control

Our 2-Pyridinecarbonitrile, 3-Fluoro-4-Methyl-, 1-Oxide (9Ci) is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and commercial projects requiring material that meets stringent internal standards, with the capability to align with cGMP guidelines as needed.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.