Description

20-Isopropylidene Prostaglandin E2 is a chemically modified prostaglandin analog, specifically a prostaglandin E2 derivative featuring an isopropylidene protecting group. This modification enhances its stability and makes it a valuable synthetic intermediate in advanced pharmaceutical research and development. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for the synthesis of novel therapeutic agents, particularly in the fields of ophthalmology, dermatology, and reproductive medicine.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of potent prostaglandin-based drugs.
• Ophthalmic Drug Research: Used in developing prostaglandin analogs for glaucoma treatment, such as latanoprost and travoprost precursors.
• Dermatological Formulations: Serves as a precursor for compounds under investigation for hair growth stimulation and skin condition treatments.
• Reproductive Medicine: Employed in research related to fertility treatments and uterine contractility modulation.
• Chemical Biology Studies: Utilized as a tool compound to study prostaglandin receptor (EP receptor) signaling pathways and functions.
• Process Development: Critical for scaling up and optimizing synthetic routes for commercial prostaglandin manufacturing.

Basic Information

Product Name	20-Isopropylidene Prostaglandin E2
CAS No.	59982-03-5
Molecular Formula	C₂₃H₃₈O₅
Molecular Weight	394.55 g/mol
Synonyms	20-Isopropylidene PGE2; (5Z)-7-[(1R,2R,3R)-3-Hydroxy-2-[(1E,3S)-3-hydroxy-4-(2,2-dimethyl-1,3-dioxolan-4-yl)but-1-en-1-yl]-5-oxocyclopentyl]hept-5-enoic Acid; 20-Acetonide Prostaglandin E2; 20-(2,2-Dimethyl-1,3-dioxolan-4-yl) Prostaglandin E2; PGE2 20-Acetonide; Isopropylidene-protected PGE2; Prostaglandin E2 20-Acetonide Derivative
EINECS	Contact for details

Quality Control

Our 20-Isopropylidene Prostaglandin E2 is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable to support our clients' regulatory and compliance needs in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation. The container should be kept in a cool, dry, and well-ventilated area, away from heat and incompatible materials. Allow the product to reach room temperature in its sealed container before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Any single unknown impurity	≤ 1.0%
Solvent Residues (GC)	Meets ICH guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.