Description

Vindesine Sulfate is a semi-synthetic vinca alkaloid derivative, a potent antineoplastic agent used in chemotherapy. Its primary value lies in its ability to inhibit microtubule formation, thereby disrupting cell division in rapidly proliferating cells. This makes it a critical active pharmaceutical ingredient (API) for the formulation of injectable oncology drugs targeting various cancers. Pharmaceutical manufacturers and research institutions globally require this high-purity compound for drug development and production.

Application

• Oncological Pharmaceutical Formulations: Primary use as the active pharmaceutical ingredient (API) in injectable chemotherapy drugs.
• Clinical Cancer Treatment: Used in regimens for acute lymphoblastic leukemia (ALL), chronic myelogenous leukemia (CML), lung cancer, breast cancer, and malignant melanoma.
• Biomedical Research: A key tool for studying microtubule dynamics, mitosis inhibition, and mechanisms of apoptosis in cell biology and oncology research.
• Drug Development & Synthesis: Serves as a reference standard and a starting material or intermediate for the synthesis of novel vinca alkaloid analogs.
• Preparation of Liposomal Formulations: Used in advanced drug delivery system research to improve therapeutic efficacy and reduce side effects.

Basic Information

Product Name	Vindesine Sulfate
CAS No.	59917-39-4
Molecular Formula	C43H55N5O7 · H2SO4
Molecular Weight	852.0 g/mol (free base: 753.9 g/mol)
Synonyms	Vindesine Sulphate; Desacetylvinblastine Amide Sulfate; Eldisine®; FCE 24517; 23-Carboxyvinblastine N-(aminocarbonyl)-O4-deacetyl- O4-(methoxycarbonyl)vinblastine sulfate; Deacetylvinblastine carboxyamide sulfate
EINECS	Contact for details

Quality Control

Our Vindesine Sulfate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for pharmaceutical use, including identity, purity, and impurity profile. Certificates of Analysis (COA) are provided, detailing results from tests such as HPLC assay, related substances, residual solvents, and microbiological examination. We support compliance with cGMP, ICH Q7, and relevant pharmacopoeial standards (e.g., USP, EP) for active pharmaceutical ingredients.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature 15-25°C (59-77°F) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 1.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	≤ 20 ppm
Bacterial Endotoxins	< 5.0 EU/mg (or as per customer requirement)
Microbial Enumeration	Complies with Ph. Eur. 2.6.12 / USP <61>

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.