Description

(S)-(-)-Malic-2,3,3-D3 Acid is a high-purity, isotopically labeled derivative of L-malic acid, a key intermediate in the Krebs cycle. This deuterated compound is essential for advanced research and development where precise metabolic tracing and analytical accuracy are paramount. It is primarily utilized by pharmaceutical R&D teams, analytical laboratories, and manufacturers of high-end diagnostic reagents requiring stable isotope-labeled internal standards.

Application

• Stable Isotope-Labeled Internal Standard for accurate quantification in LC-MS and GC-MS analysis of malic acid and related metabolites.
• Metabolic Pathway Tracing in biochemical and pharmacological research to study the Krebs cycle and energy metabolism.
• Pharmaceutical Impurity Profiling and degradation studies, serving as a reference material for method development and validation.
• NMR Spectroscopy as a deuterated probe for structural and mechanistic studies in organic chemistry and biochemistry.
• Synthesis of Labeled Compounds for use in drug discovery and development programs.
• Food & Beverage Research for isotopic studies related to flavor chemistry, fermentation processes, and authenticity testing.

Basic Information

Product Name	(S)-(-)-Malic-2,3,3-D3 Acid
CAS No.	59652-74-3
Molecular Formula	C4H3D3O5
Molecular Weight	137.11 g/mol
Synonyms	(S)-(-)-2-Hydroxybutanedioic-2,3,3-D3 Acid; (S)-(-)-Malic Acid-d3; L-Malic-2,3,3-D3 Acid; (S)-Hydroxysuccinic-2,3,3-D3 Acid; (-)-Malic-2,3,3-D3 Acid; (2S)-2-Hydroxy-1,4-butanedioic-2,3,3-D3 Acid; Apple Acid-d3; Deuterated L-Malic Acid
EINECS	Contact for details

Quality Control

Every batch of (S)-(-)-Malic-2,3,3-D3 Acid is produced and tested under strict quality management protocols. We ensure high chemical purity, isotopic enrichment, and batch-to-batch consistency suitable for sensitive analytical applications. A comprehensive Certificate of Analysis (COA) detailing assay, isotopic purity, and impurity profile is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Optical Rotation	-25° to -30° (c=1 in H2O)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.