Description

17β-Acetyl-Estradiol 3-(Tri-o-Acetyl-β-D-Glucuronic Acid Methyl Ester) is a key synthetic intermediate in the production of steroid conjugates and metabolites. This compound is of significant value for pharmaceutical research and development, particularly in the study of hormone metabolism and the synthesis of reference standards. It is primarily required by research institutions, pharmaceutical manufacturers, and analytical laboratories engaged in endocrinology, drug discovery, and bioanalytical method development.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the calibration of analytical instruments and the validation of bioanalytical methods in clinical and preclinical studies.
• Metabolite Synthesis: Serves as a crucial precursor in the chemical synthesis of estrogen glucuronide metabolites for metabolic pathway research and pharmacokinetic studies.
• Biochemical Research: Employed in enzymatic and receptor-binding assays to investigate estrogen activity, hormone signaling pathways, and endocrine-disrupting chemical effects.
• Diagnostic Development: Utilized in the development and quality control of immunoassays and LC-MS/MS kits for the precise quantification of steroid hormones in biological matrices.
• Academic Research: A vital tool for universities and research institutes studying steroid biochemistry, conjugation mechanisms, and hormone-related diseases.

Basic Information

Product Name	17β-Acetyl-Estradiol 3-(Tri-o-Acetyl-β-D-Glucuronic Acid Methyl Ester)
CAS No.	59495-70-4
Molecular Formula	C₃₆H₄₆O₁₄
Molecular Weight	702.75 g/mol
Synonyms	Estradiol 3-Glucuronide Triacetate Methyl Ester; 17β-Estradiol 3-(Tri-O-acetyl-β-D-glucopyranosiduronic Acid) Methyl Ester; 17β-Acetylestradiol 3-(Tri-O-acetyl-β-D-glucuronide) Methyl Ester; E2-3G Triacetate Methyl Ester; Estradiol-17β-acetate 3-(tri-O-acetylglucuronide) Methyl Ester; 3-Glucuronide Triacetate Methyl Ester of 17β-Acetylestradiol; 17β-Hydroxyestra-1,3,5(10)-trien-3-yl 2,3,4-tri-O-acetyl-1-(methoxycarbonyl)-β-D-glucopyranuronate
EINECS	Contact for details

Quality Control

Our 17β-Acetyl-Estradiol 3-(Tri-o-Acetyl-β-D-Glucuronic Acid Methyl Ester) is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept in a desiccated environment to prevent moisture absorption, which can affect stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.