Description

4-Hydroxydebrisoquine is a significant metabolite of the antihypertensive drug debrisoquine, primarily used in pharmacological and biochemical research. This compound is crucial for studying the cytochrome P450 2D6 (CYP2D6) enzyme system, which is responsible for the metabolism of a wide range of therapeutic drugs. Researchers and pharmaceutical developers in the fields of pharmacogenomics, drug metabolism, and toxicology rely on this high-purity reference standard to investigate metabolic pathways, enzyme kinetics, and individual variability in drug response.

Application

• Pharmacogenomic Research: Used as a probe substrate to phenotype individuals for CYP2D6 enzyme activity, a key factor in personalized medicine.
• Drug Metabolism Studies: Serves as a critical metabolite standard in in vitro and in vivo studies to understand the biotransformation of debrisoquine and related compounds.
• Analytical Reference Standard: Essential for the development and validation of analytical methods, including HPLC, LC-MS/MS, and GC-MS, for quantifying drug metabolites in biological matrices.
• Enzyme Kinetics: Employed to determine kinetic parameters (Km, Vmax) of the CYP2D6 enzyme, aiding in drug interaction studies.
• Toxicology and Safety Assessment: Used in metabolic profiling to assess potential toxicological pathways and metabolite safety.
• Biochemical Reagent: Acts as a reagent in enzymatic assays to study inhibitor or inducer effects on CYP2D6 activity.

Basic Information

Product Name	4-Hydroxydebrisoquine
CAS No.	59333-79-8
Molecular Formula	C12H15N3O
Molecular Weight	217.27 g/mol
Synonyms	4-Hydroxydebrisoquine; 1,2,3,4-Tetrahydro-2-(1H-imidazol-1-ylmethyl)-7-hydroxyisoquinoline; Debrisoquine 4-Hydroxy Metabolite; 7-Hydroxydebrisoquine; 4-OH-Debrisoquine; CYP2D6 Metabolite Standard; 2-(Imidazol-1-ylmethyl)-7-hydroxy-1,2,3,4-tetrahydroisoquinoline
EINECS	Contact for details

Quality Control

Our 4-Hydroxydebrisoquine is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for advanced research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry guidelines for reference standards to support reliable and reproducible scientific data.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at 2-8°C. Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.