Description

Phorbol-12-Tigliate-13-Decanoate is a specific, high-purity ester derivative of the phorbol diterpene core, a compound class of significant interest in biochemical research. Its defined structure makes it a valuable reference standard and a critical tool for investigating protein kinase C (PKC) signaling pathways and related cellular mechanisms. This compound is primarily utilized by research institutions and pharmaceutical development laboratories engaged in oncology, dermatology, and toxicology studies. Consistent quality and reliable supply are paramount for ensuring reproducible experimental results in these sensitive applications.

Application

• Biochemical Research: Serves as a precise reference standard and probe for studying the activation and modulation of Protein Kinase C (PKC) isoforms.
• Oncology Research: Used in vitro to investigate tumor promotion mechanisms, cell proliferation, and apoptosis signaling pathways.
• Dermatology & Toxicology Studies: Applied in research models to understand skin inflammation, irritation, and carcinogenesis processes.
• Pharmacology Development: Acts as a tool compound for screening and validating potential inhibitors of PKC and related therapeutic targets.
• Cell Signaling & Neuroscience: Employed to elucidate the role of PKC in neuronal function, synaptic plasticity, and neurodegenerative conditions.
• Academic Research: A key material for universities and institutes conducting fundamental research in cell biology and molecular pharmacology.

Basic Information

Product Name	Phorbol-12-Tigliate-13-Decanoate
CAS No.	59086-92-9
Molecular Formula	C37H56O8
Molecular Weight	628.84 g/mol
Synonyms	12-Tiglioylphorbol-13-decanoate; PDD; Phorbol 12-tigliate 13-decanoate; 4,9,12-beta,13-alpha,20-Pentahydroxytiglia-1,6-dien-3-one 12-tigliate 13-decanoate; NSC 70979; 12-O-Tigloylphorbol-13-decanoate; Phorbol-12-tigliate-13-decanoate; 12-O-Tigloyl-13-O-decanoylphorbol
EINECS	Contact for details

Quality Control

Our Phorbol-12-Tigliate-13-Decanoate is produced and handled under strict quality protocols to ensure batch-to-batch consistency and high purity, essential for research integrity. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and ensure long-term stability. Allow the sealed container to reach room temperature before opening to minimize moisture condensation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.