Description

Bestatin is a potent, low-molecular-weight aminopeptidase inhibitor derived from *Streptomyces olivoreticuli*. This compound is a critical tool for biochemical research and pharmaceutical development, primarily valued for its ability to modulate immune responses and inhibit specific enzymatic activity. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors investigating immunomodulation, enzyme kinetics, and novel therapeutic pathways.

Application

• Immunological Research: Used as a specific inhibitor of aminopeptidase N (APN/CD13) to study its role in immune cell function, antigen presentation, and inflammatory processes.
• Pharmaceutical Intermediates: Serves as a key building block or reference standard in the synthesis and development of immunomodulatory drugs and enzyme-targeted therapies.
• Biochemical Assay Development: Employed in enzymatic assays to selectively inhibit aminopeptidase activity, enabling the study of substrate specificity and enzyme kinetics.
• Cancer Research: Investigated for its potential effects on tumor cell invasion, metastasis, and angiogenesis due to its inhibition of cell surface aminopeptidases.
• Academic & Contract Research: A standard reagent in university and CRO laboratories for fundamental research in cell biology, immunology, and pharmacology.

Basic Information

Product Name	Bestatin
CAS No.	58970-76-6
Molecular Formula	C16H24N2O4
Molecular Weight	308.37 g/mol
Synonyms	Ubenimex; NK421; ((2S,3R)-3-Amino-2-hydroxy-4-phenylbutanoyl)-L-leucine; N-[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutyryl]-L-leucine; Aminopeptidase N Inhibitor; Bestatine
EINECS	261-560-9

Quality Control

Our Bestatin is produced under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. A detailed Certificate of Analysis (COA) documenting all test results is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation	-15° to -20° (c=1 in H2O)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.