Description

n-Methylmuscimol is a potent synthetic analog of the naturally occurring neuroactive compound muscimol, functioning as a selective agonist for GABAA receptors. This compound is of significant value in neuroscience research for its ability to modulate inhibitory neurotransmission, providing a critical tool for studying neurological pathways and receptor pharmacology. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on central nervous system (CNS) drug discovery and neurochemical analysis.

Application

• Neuroscience Research: A key pharmacological tool for studying GABAA receptor subtypes, function, and distribution in the brain.
• Drug Discovery & Development: Used as a reference standard and lead compound in the development of novel therapeutics targeting anxiety, epilepsy, and sleep disorders.
• Biochemical Assays: Employed in in vitro receptor binding studies and functional assays to screen for new modulators of the GABAergic system.
• Academic & Clinical Research: Supports fundamental research into the mechanisms of synaptic inhibition, neuronal excitability, and the pathophysiology of neurological conditions.
• Metabolite & Impurity Standard: Serves as a certified reference material (CRM) for analytical method development and quality control in related pharmaceutical synthesis.

Basic Information

Product Name	n-Methylmuscimol
CAS No.	58893-38-2
Molecular Formula	C5H9N3O2
Molecular Weight	143.14 g/mol
Synonyms	5-(Aminomethyl)-3-hydroxyisoxazole; 3-Hydroxy-5-(aminomethyl)isoxazole; 5-(Aminomethyl)-3-isoxazolol; Methylmuscimol; 3-Hydroxy-5-(aminomethyl)-1,2-oxazole; (5-Methyl-3-isoxazolyl)methanamine; GABAA receptor agonist
EINECS	Contact for details

Quality Control

Our n-Methylmuscimol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination, NMR and IR for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.