Description

Glutamic Acid, L-, [1,5-14C] is a carbon-14 radiolabeled form of the essential amino acid L-Glutamic acid, specifically labeled at the 1 and 5 carbon positions. This compound is a critical tool for advanced metabolic and biochemical research, enabling precise tracking of glutamic acid pathways in biological systems. It is primarily utilized by research scientists and pharmaceutical developers in the fields of neuroscience, metabolism, and drug discovery.

Application

• Metabolic Pathway Tracing: Used to study the Krebs cycle, amino acid metabolism, and neurotransmitter synthesis pathways in vitro and in vivo.
• Neuroscience Research: Essential for investigating the role of glutamic acid as an excitatory neurotransmitter, including studies on receptor binding, uptake, and release.
• Drug Metabolism and Pharmacokinetics (DMPK): Serves as a radiolabeled tracer in ADME (Absorption, Distribution, Metabolism, Excretion) studies for pharmaceutical compounds targeting glutamatergic systems.
• Biochemical Assay Development: Employed in the development and validation of enzymatic assays and diagnostic tests.
• Plant and Microbial Physiology: Applied in research on nitrogen assimilation and amino acid biosynthesis in plants and microorganisms.

Basic Information

Product Name	Glutamic Acid, L-, [1,5-14C]
CAS No.	58710-76-2
Molecular Formula	C5H914CO4 *
Molecular Weight	Contact for details
Synonyms	(2S)-2-Aminopentanedioic-1,5-14C acid; L-Glutamic-1,5-14C acid; (S)-2-Aminopentanedioic-1,5-14C acid; Glutamic Acid-1,5-14C; H-Glu-OH-1,5-14C; 14C-L-Glutamic acid; L-Glutamate-1,5-14C
EINECS	Contact for details

* Formula indicates position of carbon-14 label.

Quality Control

Every batch of our radiolabeled L-Glutamic Acid is manufactured and analyzed under strict quality systems to ensure high chemical and radiochemical purity. Quality assurance includes verification of specific activity and rigorous testing for radiochemical and chemical impurities. A comprehensive Certificate of Analysis (COA), detailing analytical methods and results from HPLC, NMR, and mass spectrometry, is provided with each shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to reach ambient temperature before opening to minimize moisture uptake. For long-term storage, keep the container in a designated, shielded area for radioactive materials, in accordance with local radiation safety regulations.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC, NMR)	Conforms to structure
Chemical Purity (HPLC)	≥ 98%
Radiochemical Purity (HPLC)	≥ 97%
Specific Activity	50-60 mCi/mmol (Contact for exact value)
Solvent (for solution forms)	Contact for details
Concentration (for solution forms)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.