Description

Benzenemethanol, -α--(1-Aminoethyl)-, Labeled With Tritium (9Ci) is a high-specific-activity radiolabeled compound, a tritiated derivative of the chiral amino alcohol 1-amino-1-phenylethanol. This product is essential for advanced research requiring high-sensitivity detection and metabolic pathway tracing, offering a powerful tool for pharmacokinetic and biochemical studies. It is primarily used by pharmaceutical R&D teams, contract research organizations (CROs), and academic institutions engaged in drug discovery and development.

Application

• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used as a radiolabeled tracer to investigate the absorption, distribution, metabolism, and excretion (ADME) of pharmaceutical candidates in preclinical models.
• Receptor Binding Assays: Serves as a high-affinity ligand in competitive binding studies to characterize receptor-ligand interactions and determine binding constants.
• Enzyme Mechanism Studies: Employed to elucidate enzymatic reaction pathways, including stereoselective transformations, by tracking the tritium label.
• Metabolite Identification: Facilitates the detection and structural elucidation of low-abundance metabolites in complex biological matrices using radiometric detection.
• Biochemical Pathway Analysis: Enables precise tracking of biochemical precursors and intermediates in biosynthetic or catabolic pathways.
• Quality Control for Radiolabeled Synthesis: Acts as a reference standard for the synthesis and purification of other tritium-labeled compounds.

Basic Information

Product Name	Benzenemethanol, -α--(1-Aminoethyl)-, Labeled With Tritium (9Ci)
CAS No.	58550-13-3
Molecular Formula	C9H11NO (Tritium labeled)
Molecular Weight	~149.19 g/mol (unlabeled)
Synonyms	1-Amino-1-phenylethanol (tritiated); (RS)-1-Amino-1-phenylethanol-[³H]; α-(1-Aminoethyl)benzyl alcohol (tritium labeled); DL-1-Phenyl-1-aminoethanol-[³H]; (±)-1-Amino-1-phenylethanol (³H); Phenylglycinol derivative (tritiated); Tritiated 1-amino-1-phenylethanol
EINECS	Contact for details

Quality Control

Every batch of this high-specific-activity radiolabeled compound is manufactured and analyzed under strict quality systems. Product identity, radiochemical purity, and specific activity are verified using advanced analytical techniques including HPLC with radiometric detection. A comprehensive Certificate of Analysis (COA) detailing the specific activity (9Ci/mmol), radiochemical purity, and analytical methods is provided with each shipment to ensure traceability and compliance with research standards.

Storage

Preserve in a tightly closed container, protected from light. Store at or below -20°C in the original solvent as supplied. For long-term storage, keep at -70°C to -80°C. This product is intended for research use only by trained personnel in appropriately equipped laboratories following all applicable radiation safety regulations.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow solution
Identification (HPLC/MS)	Conforms to reference
Specific Activity	~9 Ci/mmol
Radiochemical Purity (HPLC)	≥ 95%
Chemical Purity (HPLC)	≥ 98%
Concentration	1.0 mCi/mL (typical)
Solvent	Ethanol or custom solvent

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.