Description

9-cis-Retinoic Acid Methyl Ester is a synthetic derivative of vitamin A, specifically the methyl ester of 9-cis-retinoic acid. This compound is a critical intermediate and reference standard in pharmaceutical research, particularly for studying retinoid signaling pathways and their role in cellular differentiation and proliferation. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced life science sectors developing novel therapeutics.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel retinoid-based drugs targeting dermatological conditions and certain cancers.
• Biochemical Research: Used as a reference standard and ligand in studies of nuclear receptors like RXR (Retinoid X Receptor) to understand gene regulation and cell signaling.
• Cell Culture & Differentiation Studies: Employed in *in vitro* assays to induce and study cellular differentiation pathways in various cell lines.
• Metabolite Analysis: Serves as a standard for the analytical quantification of retinoid metabolites in biological samples via HPLC or LC-MS.
• Cosmeceutical R&D: Investigated for potential applications in advanced skincare formulations targeting photoaging and skin repair at the molecular level.

Basic Information

Product Name	9-cis-Retinoic Acid Methyl Ester
CAS No.	58526-50-4
Molecular Formula	C21H30O2
Molecular Weight	314.46 g/mol
Synonyms	Methyl 9-cis-Retinoate; 9-cis-Retinyl Methyl Ester; (2E,4E,6Z,8E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic Acid Methyl Ester; 9-cis-Retinoic Acid, Methyl Ester; Alitretinoin Methyl Ester; 9-cis-RA Methyl Ester; Panretin Methyl Ester (related)
EINECS	Contact for details

Quality Control

Our 9-cis-Retinoic Acid Methyl Ester is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder or solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0% (Area %)
Related Substances (HPLC)	Total impurities ≤ 2.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.