Description

4-Aminobutyric Acid-15N is a stable isotope-labeled analog of the essential neurotransmitter γ-aminobutyric acid (GABA), where the nitrogen atom is enriched with the 15N isotope. This labeled compound is a critical tool in biomedical and pharmaceutical research, enabling precise metabolic pathway tracing, pharmacokinetic studies, and quantitative analysis via mass spectrometry. It is primarily utilized by research institutions, pharmaceutical developers, and diagnostic companies focused on neuroscience, metabolism, and the development of novel therapeutic agents.

Application

• Internal Standard for Quantitative Analysis: Serves as a crucial internal standard in LC-MS and GC-MS assays for the accurate quantification of endogenous GABA levels in biological samples (e.g., plasma, cerebrospinal fluid, tissue homogenates).
• Metabolic Pathway Tracing: Used in 15N isotopic labeling studies to elucidate the biosynthesis, catabolism, and flux of GABA in neurological and metabolic research.
• Drug Metabolism and Pharmacokinetics (DMPK): Employed in tracing the metabolic fate of GABAergic drugs and prodrugs, aiding in the understanding of absorption, distribution, metabolism, and excretion (ADME).
• Neuroscience Research: Facilitates advanced studies on GABA receptor function, synaptic transmission, and the role of GABA in various neurological disorders.
• Diagnostic Assay Development: Integral to the development and calibration of high-sensitivity clinical diagnostic tests for inborn errors of metabolism related to the GABA shunt.

Basic Information

Product Name	4-Aminobutyric Acid-15N
CAS No.	58485-43-1
Molecular Formula	C4H915NO2
Molecular Weight	104.10 g/mol (for 15N labeled)
Synonyms	GABA-15N; γ-Aminobutyric acid-15N; 4-Amino[15N]butyric acid; (4-15N)Aminobutanoic acid; Piperidinic acid-15N; 15N-GABA; [15N]GABA
EINECS	Contact for details

Quality Control

Every batch of 4-Aminobutyric Acid-15N is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and isotopic enrichment meet the exacting standards required for research and development. A detailed Certificate of Analysis (COA), including results for assay, isotopic purity (15N atom %), and impurity profile, is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Isotopic Purity (15N atom %)	≥98%
Chemical Purity (by HPLC)	≥99.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.