Description

Alpha,β-Methyleneadenosine-5'-Triphosphate CAS NO 58337-46-5 is a chemically modified, non-hydrolyzable analog of adenosine triphosphate (ATP). This compound is critically important for biochemical research as it acts as a potent and selective inhibitor of ATP-dependent enzymes, allowing scientists to probe enzyme mechanisms and signaling pathways. It is an essential tool for researchers in pharmaceutical development, enzymology, and molecular biology who require precise control over nucleotide-dependent processes.

Application

• Enzyme Kinetics Research: Used as a non-hydrolyzable ATP analog to study the mechanisms of ATPases, kinases, and other ATP-binding proteins.
• Signal Transduction Studies: Essential for investigating purinergic signaling pathways and the role of ATP in cellular communication.
• Pharmaceutical Screening: Serves as a key reagent in high-throughput assays to identify and characterize novel enzyme inhibitors for drug discovery.
• Structural Biology: Employed in X-ray crystallography and NMR studies to determine the structure of enzyme-ligand complexes.
• Biochemical Assay Development: Used as a stable control or reference compound in the development of diagnostic and research assays.
• Metabolic Pathway Analysis: Helps elucidate the role of ATP in metabolic regulation by selectively blocking specific enzymatic steps.

Basic Information

Product Name	Alpha,β-Methyleneadenosine-5'-Triphosphate
CAS No.	58337-46-5
Molecular Formula	C11H16N5O12P3
Molecular Weight	503.18 g/mol
Synonyms	α,β-Methylene-ATP; Adenosine 5'-(α,β-methylene)triphosphate; AMP-PCP; Adenylyl methylenediphosphonate; α,β-MeATP; Non-hydrolyzable ATP analog; ATPγCH2; CAS 58337-46-5
EINECS	Contact for details

Quality Control

Our Alpha,β-Methyleneadenosine-5'-Triphosphate is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to ISO 9001 quality management standards, and our production processes are designed to meet the rigorous demands of the life sciences industry.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Allow the product to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 3.0%
Solubility	Soluble in water or buffer solutions

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.