Description

Erythro-9-(2-Hydroxy-3-Nonyl)Adenine Hydrochloride, also known as Erythro-9-Amino-β-Hexyl-α-Methyl-9H-Purine-9-Ethanol Hydrochloride, is a high-purity, specialized purine derivative with significant biological activity. This compound is valued as a potent and selective inhibitor of cyclic nucleotide phosphodiesterases, making it a critical research tool in cellular signaling and biochemistry. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in drug discovery and fundamental life science studies. The product is supplied with a guaranteed CAS NO 58337-38-5 to ensure traceability and material integrity.

Application

• Biochemical Research: As a selective inhibitor of cyclic nucleotide phosphodiesterases (PDEs), particularly PDE1, for studying intracellular signaling pathways involving cAMP and cGMP.
• Pharmaceutical Development: A key reference standard and pharmacological tool compound in the discovery and validation of new therapeutic agents targeting cardiovascular, neurological, and inflammatory diseases.
• Cell Biology Studies: Used to investigate the role of cyclic nucleotides in cellular processes such as smooth muscle relaxation, platelet aggregation, and neuronal function.
• Enzyme Kinetics: Employed in in vitro assays to determine enzyme activity, inhibition constants (Ki/IC50), and mechanism-of-action studies for various PDE isoforms.
• Academic Research: A standard reagent in university and institutional labs for graduate and post-graduate research projects focused on molecular pharmacology.

Basic Information

Product Name	Erythro-9-(2-Hydroxy-3-Nonyl)Adenine Hydrochloride / Erythro-9-Amino-β-Hexyl-α-Methyl-9H-Purine-9-Ethanol Hydrochloride
CAS No.	58337-38-5
Molecular Formula	C₁₇H₂₈N₆O₂ • HCl
Molecular Weight	384.91 g/mol
Synonyms	EHNA Hydrochloride; Erythro-9-(2-Hydroxy-3-nonyl)adenine HCl; 9-(2-Hydroxy-3-nonyl)adenine hydrochloride; Erythro-9-Amino-2-hydroxy-3-nonyladenine HCl; Adenosine cyclic 3',5'-phosphate phosphodiesterase inhibitor; PDE1 Inhibitor; NSC 326329; 9H-Purin-9-ethanol, 9-amino-β-hexyl-α-methyl-, hydrochloride (1:1), erythro-
EINECS	Contact for details

Quality Control

Our Erythro-9-(2-Hydroxy-3-Nonyl)Adenine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the stringent requirements of research and development applications. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to guarantee traceability, batch-to-batch consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider desiccant and under an inert atmosphere to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.