Description

Cysteamine Hydrochloride, [1,2-14C] is a carbon-14 radiolabeled derivative of the aminothiol cysteamine, specifically labeled at the 1 and 2 positions of the carbon chain. This compound is essential for conducting advanced metabolic and pharmacokinetic studies, providing researchers with a precise tracer to follow the fate of cysteamine in biological systems. It is a critical tool for pharmaceutical R&D, toxicology, and biochemistry laboratories focused on drug development and metabolic pathway analysis.

Application

• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used as a radiolabeled tracer to investigate the absorption, distribution, metabolism, and excretion (ADME) of cysteamine and related drug candidates.
• Biochemical Pathway Tracing: Enables detailed mapping of cysteamine's role in metabolic processes, including its conversion to taurine or incorporation into coenzyme A.
• Pharmaceutical Research & Development: Critical for the development and regulatory submission of new therapeutics, particularly for diseases like cystinosis where cysteamine is a key active pharmaceutical ingredient (API).
• Toxicology and Safety Assessment: Facilitates studies on the biodistribution and potential long-term tissue retention of cysteamine and its metabolites.
• Radioligand Binding Assays: Can be utilized in specialized assays to study receptor interactions or enzyme mechanisms involving thiol compounds.

Basic Information

Product Name	Cysteamine Hydrochloride, [1,2-14C]
CAS No.	58246-44-9
Molecular Formula	C2H8ClNS • HCl (with 14C at positions 1 & 2)
Molecular Weight	~113.61 g/mol (unlabeled base)
Synonyms	2-Aminoethanethiol Hydrochloride, [1,2-14C]; β-Mercaptoethylamine Hydrochloride, [1,2-14C]; Mercaptamine Hydrochloride, [1,2-14C]; Decarboxycysteine Hydrochloride, [1,2-14C]; Thioethanolamine Hydrochloride, [1,2-14C]; Cystagon impurity standard (radiolabeled); HS-CH2-CH2-NH2 • HCl (14C labeled)
EINECS	Contact for details

Quality Control

Every batch of Cysteamine Hydrochloride, [1,2-14C] is manufactured and controlled under a strict quality management system. The product undergoes comprehensive analytical testing, including radiochemical purity (RCP) and chemical purity assessment by HPLC, specific activity determination, and identity confirmation. A detailed Certificate of Analysis (COA) is provided with each shipment, specifying batch-specific data for radioactivity, purity, and solvent composition.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider conditions recommended for radiolabeled compounds. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR / HPLC)	Conforms to reference standard
Radiochemical Purity (HPLC)	≥ 97%
Chemical Purity (HPLC)	≥ 95%
Specific Activity	50-60 mCi/mmol (Contact for exact value)
Solvent (if supplied in solution)	Specified on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.