Description

Propargylglycine is a non-proteinogenic amino acid featuring a reactive alkyne group, making it a valuable biochemical tool and synthetic intermediate. Its unique structure allows it to act as an irreversible inhibitor of specific enzymes, including cystathionine γ-lyase, which is critical for research in metabolic pathways and hydrogen sulfide signaling. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors who require high-purity biochemical building blocks for drug discovery and development.

Application

• Biochemical Research: Used as a potent, mechanism-based inhibitor of enzymes like cystathionine γ-lyase (CSE) to study hydrogen sulfide (H₂S) biology and transsulfuration pathways.
• Pharmaceutical Intermediates: Serves as a key chiral building block in the synthesis of novel drug candidates and active pharmaceutical ingredients (APIs).
• Metabolic Studies: Employed in cellular and animal models to investigate amino acid metabolism, oxidative stress, and related disease mechanisms.
• Enzyme Kinetics: A critical tool for characterizing enzyme activity, inhibition constants, and catalytic mechanisms in vitro.
• Proteomics & Labeling: The alkyne moiety enables bioorthogonal chemistry applications, such as click chemistry, for labeling and detecting biomolecules.
• Academic & Industrial R&D: Fundamental reagent for universities, contract research organizations (CROs), and biotech companies exploring new therapeutic targets.

Basic Information

Product Name	Propargylglycine
CAS No.	58160-95-5
Molecular Formula	C₅H₇NO₂
Molecular Weight	113.11 g/mol
Synonyms	2-Amino-4-pentynoic acid; 4-Pentynoic acid, 2-amino-; DL-Propargylglycine; (±)-2-Amino-4-pentynoic acid; Propiolylglycine; CSE Inhibitor; PAG; 2-Amino-pent-4-ynoic acid
EINECS	Contact for details

Quality Control

Our Propargylglycine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed specifications and test results are provided to guarantee traceability, consistency, and reliability for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.