Description

2,4-Di-tert-Butoxy-5-Fluoro-Pyrimidine is a high-purity, specialty fluorinated pyrimidine derivative designed for advanced synthetic chemistry. This compound serves as a critical protected intermediate, enabling the controlled introduction of the 5-fluoro-pyrimidine moiety into complex molecular architectures. It is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of active pharmaceutical ingredients (APIs), nucleoside analogs, and novel crop protection agents.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of antiviral, anticancer, and other fluorinated nucleoside-based drugs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides and fungicides containing fluoropyrimidine structures.
• Chemical Research: A versatile reagent for organic synthesis, particularly in cross-coupling reactions and nucleophilic substitutions where a protected, activated pyrimidine is required.
• Material Science: Potential precursor for the development of specialty polymers and liquid crystals with unique electronic properties.
• Process Development: Employed in scaling up synthetic routes for fluorinated target molecules in pilot plants and commercial manufacturing.

Basic Information

Product Name	2,4-Di-tert-Butoxy-5-Fluoro-Pyrimidine
CAS No.	58090-53-2
Molecular Formula	C12H19FN2O2
Molecular Weight	242.29 g/mol
Synonyms	5-Fluoro-2,4-bis(tert-butoxy)pyrimidine; 2,4-Bis(1,1-dimethylethoxy)-5-fluoropyrimidine; 5-Fluoro-2,4-di-tert-butoxypyrimidine; 2,4-Di-t-butoxy-5-fluoropyrimidine; 58090-53-2; 5-Fluoropyrimidine-2,4-diol di-tert-butyl ether
EINECS	Contact for details

Quality Control

Every batch of 2,4-Di-tert-Butoxy-5-Fluoro-Pyrimidine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing purity (typically >97% by HPLC), identity confirmation, and impurity profile is supplied with each shipment. Our quality commitment supports compliance in cGMP and ISO 9001 environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container tightly sealed to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.