Description

1-Butanone, 2-Fluoro-3-Hydroxy-1-Phenyl-, (R*,R*)- (9Ci) is a chiral fluorinated hydroxy ketone building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of complex, biologically active molecules, particularly in the pharmaceutical sector. It is needed by research and development chemists and process scale-up teams in pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate fluorinated stereogenic centers into their target compounds.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of fluorinated active pharmaceutical ingredients (APIs), including potential enzyme inhibitors and receptor modulators.
• Agrochemical Research: Used in the development of novel, fluorinated pesticides and herbicides where the introduction of fluorine can enhance metabolic stability and bioactivity.
• Asymmetric Synthesis: Serves as a versatile starting material or intermediate in catalytic asymmetric reactions to construct complex molecular architectures.
• Ligand and Catalyst Development: Employed in the preparation of chiral ligands and organocatalysts for use in enantioselective transformations.
• Material Science Precursor: Potential use in the synthesis of fluorinated organic compounds for advanced materials with specific optical or electronic properties.
• Academic & Contract Research: A valuable reagent for methodological studies in organic and medicinal chemistry within university and CRO (Contract Research Organization) laboratories.

Basic Information

Product Name	1-Butanone, 2-Fluoro-3-Hydroxy-1-Phenyl-, (R*,R*)- (9Ci)
CAS No.	58089-69-3
Molecular Formula	C10H11FO2
Molecular Weight	182.19 g/mol
Synonyms	(2R*,3R*)-2-Fluoro-3-hydroxy-1-phenylbutan-1-one; 2-Fluoro-3-hydroxy-1-phenyl-1-butanone (racemic diastereomer); 1-Phenyl-2-fluoro-3-hydroxy-1-butanone; α-Fluoro-β-hydroxybutyrophenone; (R*,R*)-rel-2-Fluoro-3-hydroxy-1-phenyl-1-butanone; Fluorinated hydroxy phenylbutanone; 58089-69-3
EINECS	Contact for details

Quality Control

Our production of 1-Butanone, 2-Fluoro-3-Hydroxy-1-Phenyl-, (R*,R*)- (9Ci) adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity for research and scale-up applications. All products undergo rigorous analytical testing, including HPLC, GC, NMR, and chiral analysis, to confirm identity, purity, and isomeric composition. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is sensitive to fluoride/strong alkali conditions and should be stored separately from such materials. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Diastereomeric Ratio (HPLC)	≥ 95:5 (R*,R* : other isomers)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.