Description

17β-Hydroxy Wortmannin is a potent and selective derivative of the natural product wortmannin, functioning as a covalent inhibitor of phosphoinositide 3-kinase (PI3K) and related kinases. This compound is a critical research tool for elucidating the PI3K signaling pathway, which plays a central role in cell growth, proliferation, and survival. It is essential for researchers and developers in pharmaceutical R&D, biochemical research, and cell biology studying cancer, metabolic disorders, and immune responses.

Application

• Biochemical Research: Used as a selective, covalent inhibitor to study the structure, function, and downstream effects of the PI3K signaling pathway in vitro.
• Cancer Research: A key tool for investigating the role of PI3K in tumor cell proliferation, survival, and metastasis, aiding in the development of targeted cancer therapies.
• Signal Transduction Studies: Employed to dissect complex cellular signaling networks and understand crosstalk between PI3K and other critical pathways like mTOR.
• Drug Discovery & Development: Serves as a reference compound and a starting point for the design and screening of novel PI3K inhibitors in high-throughput assays.
• Metabolic Disorder Research: Utilized in studies exploring insulin signaling, glucose homeostasis, and the metabolic actions of PI3K in various tissue types.
• Immunology Research: Applied to investigate the role of PI3K isoforms in immune cell activation, differentiation, and inflammatory responses.

Basic Information

Product Name	17β-Hydroxy Wortmannin
CAS No.	58053-83-1
Molecular Formula	C23H24O8
Molecular Weight	428.43 g/mol
Synonyms	17β-Hydroxywortmannin; 17-Hydroxywortmannin; (11β,17β)-11,17-Dihydroxy-3-oxoandrosta-1,4-diene-2-carboxylic acid 17-acetate 2,17-lactone; PI3K Inhibitor VIII; Wortmannin, 17-hydroxy-; 17beta-Hydroxy-wortmannin
EINECS	Contact for details

Quality Control

Our 17β-Hydroxy Wortmannin is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. Allow the product to equilibrate to room temperature in a desiccator before opening to prevent moisture condensation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Yellow to light brown solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.