Description

3-Nitrophenylmethanesulfonyl Chloride is a versatile and highly reactive sulfonyl chloride derivative, primarily used as a key building block in organic synthesis. Its value lies in its ability to act as a sulfonylation reagent, facilitating the introduction of the mesyl (methanesulfonyl) group into target molecules, which is crucial for modifying physicochemical properties and biological activity. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, particularly in the development of active pharmaceutical ingredients (APIs), intermediates, and functional materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, especially those containing sulfonamide moieties with potential therapeutic applications.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the sulfonyl group can enhance efficacy and selectivity.
• Peptide Chemistry: Employed as a sulfonylation agent for protecting groups or for modifying amino acid side chains during peptide synthesis.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers and functional organic materials.
• Chemical Biology Probes: Utilized to create activity-based probes for studying enzyme function and protein interactions in biochemical research.
• Dye and Pigment Intermediate: Acts as a key intermediate in the synthesis of complex organic dyes and colorants.

Basic Information

Product Name	3-Nitrophenylmethanesulfonyl Chloride
CAS No.	58032-84-1
Molecular Formula	C7H6ClNO4S
Molecular Weight	235.64 g/mol
Synonyms	3-Nitrobenzenemethanesulfonyl chloride; m-Nitrobenzenemethanesulfonyl chloride; 1-(Chlorosulfonylmethyl)-3-nitrobenzene; 3-Nitro-α-toluenesulfonyl chloride; Mesyl chloride, 3-nitrophenyl-; (3-Nitrophenyl)methanesulfonyl chloride; NSC 163083
EINECS	Contact for details

Quality Control

Our 3-Nitrophenylmethanesulfonyl Chloride is manufactured under strict quality management protocols. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and industrial synthesis. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.