Description

(+)-5-Trans Cloprostenol CAS NO 57968-81-7 is a high-purity, synthetic prostaglandin analog, specifically the biologically active 5-trans isomer of cloprostenol. This compound is valued for its potent luteolytic and smooth muscle-contracting properties, making it a critical intermediate in advanced pharmaceutical synthesis. It is primarily required by manufacturers in the veterinary pharmaceutical and biotechnology sectors for developing fertility management and therapeutic products.

Application

• Veterinary Pharmaceuticals: Key active pharmaceutical ingredient (API) or intermediate in formulations for estrus synchronization and the treatment of reproductive disorders in livestock.
• Biotechnology Research: Used as a reference standard and a crucial reagent in prostaglandin receptor (FP receptor) studies and pharmacological research.
• Advanced Drug Synthesis: Serves as a vital chiral building block for the synthesis of more complex prostaglandin-based therapeutics.
• Animal Health Products: A core component in manufacturing injectable solutions for controlled breeding programs in dairy and beef cattle.

Basic Information

Product Name	(+)-5-Trans Cloprostenol
CAS No.	57968-81-7
Molecular Formula	C22H29ClO6
Molecular Weight	424.91 g/mol
Synonyms	(+)-5-Trans Cloprostenol; 5-trans-Cloprostenol; (5Z)-7-[(1R,2R,3R,5S)-2-[(1E,3R)-4-(3-Chlorophenoxy)-3-hydroxybut-1-en-1-yl]-3,5-dihydroxycyclopentyl]hept-5-enoic Acid; Cloprostenol 5-trans Isomer; PGF2α Analog; ICI 80996 (5-trans isomer); Prostamate (related)
EINECS	Contact for details

Quality Control

Our (+)-5-Trans Cloprostenol is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the stringent requirements for pharmaceutical intermediate use. Certificates of Analysis (COA) detailing identity, purity, and related substances are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled temperature of 2-8°C to maintain stability and prevent oxidation. Keep the container in a dry, cool, and well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (5-trans isomer)	≥ 99.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.