Description

20-Hydroxyprostaglandin E1 is a bioactive metabolite of Prostaglandin E1 (Alprostadil) and a key intermediate in the study of eicosanoid signaling pathways. This compound is of significant interest for its role in vascular and inflammatory biology research, serving as a crucial reference standard and synthetic precursor. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and contract manufacturing organizations (CMOs) focused on cardiovascular, renal, and metabolic disease therapeutics.

Application

• Pharmaceutical Reference Standard: Used for the qualitative and quantitative analysis of Prostaglandin E1 and its metabolites in drug development and quality control.
• Biochemical Research: A vital tool for investigating the physiological and pathological roles of prostaglandin metabolites in cellular signaling, inflammation, and vascular tone regulation.
• Synthetic Intermediate: Serves as a key building block in the organic synthesis of novel prostaglandin analogs and related bioactive molecules.
• Metabolite Studies: Essential for pharmacokinetic and metabolic pathway studies of Alprostadil and other prostaglandin-based therapeutics.
• In Vitro Diagnostics (IVD): May be used in the development of enzyme immunoassays (EIAs) and other diagnostic kits targeting prostaglandin pathways.

Basic Information

Product Name	20-Hydroxyprostaglandin E1
CAS No.	57930-99-1
Molecular Formula	C₂₀H₃₄O₆
Molecular Weight	370.48 g/mol
Synonyms	20-Hydroxy-PGE1; 20-Hydroxyalprostadil; 20-Hydroxy-PGE1; 20(R)-Hydroxyprostaglandin E1; 20(S)-Hydroxyprostaglandin E1; 11α,15-Dihydroxy-20-hydroxy-9-oxoprost-13-en-1-oic acid; PGE1 alcohol; 20-OH-PGE1
EINECS	Contact for details

Quality Control

Our 20-Hydroxyprostaglandin E1 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by spectroscopic methods (IR, NMR, MS), and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. The product is light-sensitive and easily oxidized; allow it to reach room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.