Description

Domperidone is a potent and selective dopamine D2 and D3 receptor antagonist, widely recognized for its antiemetic and gastroprokinetic properties. This high-purity active pharmaceutical ingredient (API) is essential for ensuring the efficacy and safety of finished pharmaceutical formulations. It is primarily utilized by pharmaceutical manufacturers and research institutions in the development and production of medications for gastrointestinal motility disorders and nausea control.

Application

• Pharmaceutical API: Core active ingredient in prescription medications for treating nausea and vomiting.
• Gastroprokinetic Agent: Used in formulations to manage symptoms of gastroparesis, such as bloating, discomfort, and early satiety.
• Antiemetic Therapy: Key component in drugs prescribed for chemotherapy-induced or postoperative nausea and vomiting.
• Gastroesophageal Reflux Disease (GERD) Management: Incorporated into therapeutic regimens to improve gastric emptying and reduce reflux.
• Veterinary Medicine: Employed in veterinary pharmaceuticals for similar gastrointestinal indications in animals.
• Research & Development: Serves as a critical reference standard and building block in pharmacological and clinical research.
• Generic Drug Manufacturing: Sourced by generic drug producers for cost-effective, bioequivalent product development.

Basic Information

Product Name	Domperidone
CAS No.	57808-66-9
Molecular Formula	C22H24ClN5O2
Molecular Weight	425.91 g/mol
Synonyms	5-Chloro-1-[1-[3-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)propyl]piperidin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one; Motilium; Domperidonum; Domperidona; Dompéridone; R 33812; ABT-259; EINECS 261-047-7
EINECS	261-047-7

Quality Control

Our Domperidone is manufactured under strict quality management systems, targeting compliance with major pharmacopoeial standards such as USP and EP. Each batch undergoes comprehensive analytical testing including identification, assay, impurity profiling, and residual solvent analysis. A Certificate of Analysis (COA) documenting all test results is provided to ensure full traceability and quality assurance for our clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White or almost white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity: ≤ 0.15% Total impurities: ≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.