Description

Vincathicine CAS NO 57665-10-8 is a high-purity, semi-synthetic vinca alkaloid derivative of significant interest in advanced pharmaceutical research and development. This compound is valued for its potential as a key intermediate in the synthesis of novel chemotherapeutic agents targeting specific cellular pathways. It is primarily utilized by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers engaged in oncology drug discovery and process development. Our supply is characterized by stringent quality control to ensure batch-to-batch consistency and reliability for critical applications.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of investigational anti-cancer drugs and novel vinca alkaloid analogs.
• Biochemical Research: Used in in vitro studies to investigate mechanisms of tubulin binding, mitotic inhibition, and apoptosis induction.
• Reference Standard: Employed as an analytical standard in HPLC and LC-MS methods for quality control and impurity profiling of related pharmaceutical products.
• Process Development: Utilized in scaling up and optimizing synthetic routes for the production of next-generation chemotherapeutic agents.
• Academic Research: Supports university and institutional research programs focused on medicinal chemistry and cancer biology.

Basic Information

Product Name	Vincathicine
CAS No.	57665-10-8
Molecular Formula	C46H56N4O10
Molecular Weight	824.97 g/mol
Synonyms	Vincathicine; 4'-Deoxy-4'-epivincaleukoblastine; 4'-Deoxy-4'-epivincaleucoblastine; 4'-Deoxy-4'-epi-VLB; 4'-Deoxy-4'-epivinblastine; (3aR,4R,5S,5aR,10bR,13aR)-4-(Acetyloxy)-3a-ethyl-9-((5S,7R,9S)-5-ethyl-5-hydroxy-9-(methoxycarbonyl)-1,4,5,6,7,8,9,10-octahydro-2H-3,7-methanoazacycloundecino[5,4-b]indol-9-yl)-5-hydroxy-8-methoxy-6-methyl-3a,4,5,5a,6,11,12,13a-octahydro-1H-indolizino[8,1-cd]carbazole-5-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our Vincathicine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by spectroscopic methods (IR, NMR), and residual solvent analysis to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) detailing all test results are provided with every shipment. We can support development projects requiring compliance with ICH guidelines for impurities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant use and storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.