Description

(10R)-10,11-Dihydro-8-Chloro-10-[(3R)-3-(Methylethylamino)Pyrrolizino]Dibenzo[B,F]Thiepin CAS NO 57602-87-6 is a high-purity, complex heterocyclic organic compound featuring a dibenzothiepin core structure with a chiral pyrrolizino substituent. This compound is of significant value in advanced pharmaceutical research and development, particularly as a sophisticated chemical intermediate or a potential active pharmaceutical ingredient (API) precursor. It is primarily needed by R&D laboratories, pharmaceutical manufacturers, and fine chemical synthesis companies working on novel therapeutic agents, especially in the areas of central nervous system (CNS) and psychotropic drug discovery.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral building block in the multi-step synthesis of novel drug candidates.
• Active Pharmaceutical Ingredient (API) Research: Used as a precursor or reference standard in the development and analytical profiling of new chemical entities.
• Medicinal Chemistry & Drug Discovery: Provides a complex, functionalized scaffold for structure-activity relationship (SAR) studies and lead optimization programs.
• Biochemical Research: Employed in studies investigating interactions with biological targets such as receptors or enzymes.
• Reference Standard: Acts as a high-purity standard for analytical method development, validation, and quality control (HPLC, GC, NMR).
• Asymmetric Synthesis: Utilized in chiral synthesis due to its defined stereochemistry at multiple centers, supporting the production of enantiomerically pure compounds.

Basic Information

Item	Detail
Product Name	(10R)-10,11-Dihydro-8-Chloro-10-[(3R)-3-(Methylethylamino)Pyrrolizino]Dibenzo[B,F]Thiepin
CAS No.	57602-87-6
Molecular Formula	C22H24ClN2S
Molecular Weight	383.96 g/mol
Synonyms	8-Chloro-10,11-dihydro-10-[(3R)-3-(isopropylamino)pyrrolidin-1-yl]dibenzo[b,f]thiepin; (R)-8-Chloro-10,11-dihydro-10-((R)-3-(isopropylamino)pyrrolidin-1-yl)dibenzo[b,f]thiepin; Dibenzo[b,f]thiepin, 8-chloro-10,11-dihydro-10-[(3R)-3-[(1-methylethyl)amino]-1-pyrrolidinyl]-, (10R)-; Zotepine Impurity; Zotepine Related Compound; Zotepine Intermediate; Chiral Dibenzo[b,f]thiepin Derivative
EINECS	Contact for details

Quality Control

Our (10R)-10,11-Dihydro-8-Chloro-10-[(3R)-3-(Methylethylamino)Pyrrolizino]Dibenzo[B,F]Thiepin is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical research. Certificates of Analysis (COA) detailing specifications such as assay, chiral purity, and impurity profiles are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. This compound may be hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.