Description

Elagolix-001 is a high-purity, non-peptide small molecule compound designed for advanced pharmaceutical research and development. This active pharmaceutical ingredient (API) is a potent and selective antagonist of the gonadotropin-releasing hormone (GnRH) receptor, offering significant therapeutic potential. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and academic research institutions focused on developing treatments for hormone-dependent conditions such as endometriosis and uterine fibroids.

Application

• Pharmaceutical API Synthesis: Serves as the core active ingredient in the formulation of finished drug products.
• Endometriosis Treatment R&D: Key component in clinical and preclinical research for developing non-surgical, long-term management therapies.
• Uterine Fibroids (Leiomyomas) Research: Used in studies targeting the reduction of fibroid size and associated symptoms.
• GnRH Receptor Antagonist Studies: A critical reference standard in pharmacological research to study receptor binding and signal transduction pathways.
• Formulation Development: Employed in the development of various dosage forms, including oral tablets.
• Analytical Reference Standard: Used in quality control laboratories for method development, validation, and assay calibration (HPLC, LC-MS).

Basic Information

Product Name	Elagolix-001
CAS No.	110143-62-9
Molecular Formula	C32H30F5N5O4
Molecular Weight	643.60 g/mol
Synonyms	Elagolix; Elagolix Sodium; NBI-56418; 4-[[(1R)-2-[5-(2-Fluoro-3-methoxyphenyl)-3-[[2-fluoro-6-(trifluoromethyl)benzoyl]amino]-2-pyridinyl]-1-phenylethyl]amino]-4-oxobutanoic Acid; 4-({(1R)-2-[5-(2-Fluoro-3-methoxyphenyl)-3-({[2-fluoro-6-(trifluoromethyl)phenyl]carbonyl}amino)-2-pyridinyl]-1-phenylethyl}amino)-4-oxobutanoic Acid; Orilissa (Brand Name); AbbVie-001 (Development Code)
EINECS	Contact for details

Quality Control

Our Elagolix-001 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and potency, aligning with ICH guidelines. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting results for assay, related substances, residual solvents, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.