Description

Vasopressin, Gly-Lys-Arg-8-Lys- CAS NO 100442-96-4 is a synthetic peptide analog of the endogenous hormone vasopressin, specifically modified with a Gly-Lys-Arg extension at the N-terminus and a Lysine substitution at position 8. This compound is of significant interest for advanced biochemical and pharmacological research due to its potential for modified receptor binding affinity and metabolic stability compared to native vasopressin. It serves as a critical intermediate and reference standard for pharmaceutical R&D, particularly in the development of novel therapeutics targeting vasopressin and oxytocin receptor pathways.

Application

• Pharmaceutical Research & Development: As a key intermediate in the synthesis of novel peptide-based drugs targeting cardiovascular, renal, and central nervous system disorders.
• Biochemical Research: Used as a reference standard and tool compound for studying vasopressin receptor (V1a, V1b, V2) signaling, selectivity, and downstream effects.
• Peptide Chemistry Studies: Serves as a model compound for investigating structure-activity relationships (SAR), peptide stability, and modification strategies.
• Diagnostic Development: Potential use in the development of immunoassays and diagnostic kits for conditions related to vasopressin pathway dysregulation.
• Academic & Institutional Research: Supplied to universities and research institutes for fundamental studies in endocrinology, neurobiology, and molecular pharmacology.

Basic Information

Product Name	Vasopressin, Gly-Lys-Arg-8-Lys- CAS NO 100442-96-4
CAS No.	100442-96-4
Molecular Formula	C53H84N18O15S2
Molecular Weight	1229.5 g/mol
Synonyms	[Gly-Lys-Arg]-Vasopressin, Lys8-Vasopressin; [Gly1,Lys8]Vasopressin; GKR-AVP; 8-Lysine-vasopressin; Argipressin, Gly-Lys-Arg-8-Lys- analog; Vasopressin (8-Lys) fragment 1-9; H-Gly-Lys-Arg-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2 (disulfide bridge: Cys1-Cys6)
EINECS	Contact for details

Quality Control

Our Vasopressin, Gly-Lys-Arg-8-Lys- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide full traceability and Certificates of Analysis (COA) are available for all shipments, detailing purity, content, and related substance profiles to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, desiccate and keep frozen. Allow the vial to reach room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Individual impurity ≤ 2.0%
Total Impurities	≤ 5.0%
Amino Acid Composition	Conforms to theoretical values
Water Content (KF)	≤ 8.0%
Peptide Content	≥ 80.0% (by AAA)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.