Description

11β,17,21-Tris(Trimethylsiloxy)-5β-Pregnane-3,20-Dione Bis(o-Methyl Oxime) is a high-purity, advanced steroid derivative used as a critical synthetic intermediate in pharmaceutical research and development. This compound is valued for its role in the synthesis of complex steroid-based active pharmaceutical ingredients (APIs) and reference standards. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and academic laboratories engaged in steroid chemistry and drug discovery.

Application

• Pharmaceutical Intermediate: Key building block in the multi-step synthesis of complex steroid hormones and their analogs.
• Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control in pharmaceutical analysis.
• Research & Development: Essential reagent in medicinal chemistry programs focused on developing new therapeutic agents targeting hormone receptors.
• Process Chemistry: Employed in scaling up synthetic routes for the production of steroid-based active pharmaceutical ingredients (APIs).
• Metabolite Synthesis: Used in the preparation of specific steroid metabolites for pharmacological and toxicological studies.

Basic Information

Product Name	11β,17,21-Tris(Trimethylsiloxy)-5β-Pregnane-3,20-Dione Bis(o-Methyl Oxime)
CAS No.	57363-09-4
Molecular Formula	C32H60N2O5Si3
Molecular Weight	637.10 g/mol
Synonyms	11β,17,21-Tris(trimethylsilyloxy)-5β-pregnane-3,20-dione bis(O-methyloxime); 5β-Pregnane-3,20-dione, 11β,17,21-tris[(trimethylsilyl)oxy]-, bis(O-methyloxime); Tris(trimethylsiloxy) pregnane dione bis(o-methyl oxime); Steroid TMS derivative; 57363-09-4; 11β,17,21-Tris-O-(trimethylsilyl) Derivative
EINECS	Contact for details

Quality Control

Our 11β,17,21-Tris(Trimethylsiloxy)-5β-Pregnane-3,20-Dione Bis(o-Methyl Oxime) is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.