Description

[[(20R)-5β-Pregnane-3α,11β,20,21-Tetryl]Tetra(Oxy)]Tetrakis(Trimethylsilane) CAS NO 57326-08-6 is a high-purity, organosilicon-protected derivative of a pregnane steroid, specifically designed for advanced synthetic and research applications. This compound is valued for its role as a key synthetic intermediate, where the trimethylsilyl (TMS) groups provide excellent protection for hydroxyl functionalities during complex multi-step organic synthesis. It is primarily utilized by research institutions and pharmaceutical development laboratories engaged in the synthesis of novel steroid-based compounds, hormone analogs, and other bioactive molecules. The product's defined stereochemistry and protective groups offer critical control and efficiency in sophisticated chemical transformations.

Application

• Pharmaceutical Intermediate: Serves as a crucial protected intermediate in the multi-step synthesis of novel steroid-based active pharmaceutical ingredients (APIs) and hormone analogs.
• Organic Synthesis Building Block: Used in advanced organic chemistry research for the construction of complex molecular architectures, leveraging its protected hydroxyl groups for selective reactions.
• Biochemical Research: Employed in the study of steroid metabolism, receptor binding, and the development of labeled tracers or probes for diagnostic research.
• Process Chemistry Development: Utilized in route scouting and optimization within process R&D for the scalable production of high-value steroid derivatives.
• Reference Standard: Acts as a high-purity chemical reference standard for analytical method development and quality control in steroid synthesis.

Basic Information

Product Name	[(20R)-5β-Pregnane-3α,11β,20,21-Tetryl]Tetra(Oxy)]Tetrakis(Trimethylsilane)
CAS No.	57326-08-6
Molecular Formula	C40H84O4Si4
Molecular Weight	741.5 g/mol (approx.)
Synonyms	5β-Pregnane-3α,11β,20,21-tetrol, tetra-TMS ether; 3α,11β,20,21-Tetrakis(trimethylsilyloxy)-5β-pregnan-20-ol; Pregnane-3α,11β,20,21-tetrol tetrakis(trimethylsilyl) ether; Tetrakis-O-(trimethylsilyl) derivative of 5β-pregnane-3α,11β,20,21-tetrol; Steroid TMS ether intermediate; Protected pregnane tetrol
EINECS	Contact for details

Quality Control

Our [(20R)-5β-Pregnane-3α,11β,20,21-Tetryl]Tetra(Oxy)]Tetrakis(Trimethylsilane) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and spectroscopic identification (NMR, IR), to ensure it meets exacting research and development standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment, and consideration should be given to handling under an inert atmosphere for long-term storage of opened containers to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.