Description

11β,17,21-Tris(Trimethylsiloxy)-5α-Pregnane-3,20-Dione Bis(o-Methyl Oxime) is a high-purity, advanced steroid derivative used as a critical synthetic intermediate in pharmaceutical research and development. This compound is valued for its role in the synthesis of complex steroid-based molecules, where its protected functional groups enable precise chemical transformations. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, particularly in the fields of endocrinology and anti-inflammatory drug discovery.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of complex steroid hormones and their analogs.
• Research & Development: Used in medicinal chemistry for the discovery and optimization of new drug candidates targeting steroid receptors.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in analytical laboratories.
• Process Chemistry: Employed in scale-up and process optimization for the production of active pharmaceutical ingredients (APIs).
• Biochemical Research: Utilized in studies investigating steroid metabolism, receptor binding, and signal transduction pathways.

Basic Information

Product Name	11β,17,21-Tris(Trimethylsiloxy)-5α-Pregnane-3,20-Dione Bis(o-Methyl Oxime)
CAS No.	57325-81-2
Molecular Formula	C₃₃H₆₂N₂O₆Si₃
Molecular Weight	659.11 g/mol
Synonyms	5α-Pregnane-3,20-dione, 11β,17,21-tris[(trimethylsilyl)oxy]-, bis(O-methyloxime); 11β,17,21-Tris-O-(trimethylsilyl)-5α-pregnane-3,20-dione dioxime methyl ether; Tris(trimethylsilyl) Derivative of 5α-Pregnane-3,20-dione Bis(o-Methyl Oxime); TMS Derivative of Pregnane Dioxime Methyl Ether; Steroid TMS Ether Derivative; Contact for details on additional trade names.
EINECS	Contact for details

Quality Control

Our 11β,17,21-Tris(Trimethylsiloxy)-5α-Pregnane-3,20-Dione Bis(o-Methyl Oxime) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and performance.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.