Description

Benzo(A)Pyrene-7,8-Diol is a crucial dihydrodiol metabolite of the environmental pollutant benzo[a]pyrene, widely used as a key intermediate in toxicological and metabolic research. Its significance lies in its role as a precursor to the ultimate carcinogenic metabolite, benzo[a]pyrene-7,8-diol-9,10-epoxide, making it essential for studying metabolic activation pathways and DNA adduct formation. This compound is primarily needed by research institutions, pharmaceutical R&D departments, and environmental testing laboratories focused on polycyclic aromatic hydrocarbon (PAH) metabolism, chemical carcinogenesis, and biomarker development.

Application

• Biochemical Research: Critical intermediate for studying the metabolic activation pathways of benzo[a]pyrene (BaP) and related PAHs.
• Toxicology Studies: Used in in vitro and in vivo models to investigate the mechanisms of chemical carcinogenesis and mutagenicity.
• Metabolite Standard: Serves as a high-purity analytical standard for the identification and quantification of BaP metabolites in biological samples via HPLC, LC-MS, or GC-MS.
• DNA Adduct Research: Employed in experiments to form and characterize DNA adducts, helping to elucidate the molecular basis of PAH-induced genotoxicity.
• Enzyme Activity Assays: Used as a substrate to study the activity and specificity of cytochrome P450 enzymes (e.g., CYP1A1, CYP1B1) and epoxide hydrolase.
• Environmental Monitoring: Acts as a reference compound in assays designed to detect and measure human exposure to carcinogenic PAHs.
• Pharmaceutical Development: Utilized in screening programs for chemopreventive agents that inhibit the metabolic activation of procarcinogens.

Basic Information

Item	Details
Product Name	Benzo(A)Pyrene-7,8-Diol
CAS No.	57303-99-8
Molecular Formula	C20H14O2
Molecular Weight	286.32 g/mol
Synonyms	Benzo[a]pyrene-7,8-diol; 7,8-Dihydroxy-7,8-dihydrobenzo[a]pyrene; BP-7,8-diol; (±)-Benzo[a]pyrene-7,8-dihydrodiol; trans-Benzo[a]pyrene-7,8-dihydrodiol; B[a]P-7,8-diol; 7,8-Dihydroxybenzo[a]pyrene; 7,8-Dihydro-7,8-dihydroxybenzo[a]pyrene
EINECS	Contact for details

Quality Control

Our Benzo(A)Pyrene-7,8-Diol is produced and handled under strict quality protocols to ensure high purity and batch-to-batch consistency, essential for sensitive research applications. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. A detailed Certificate of Analysis (COA) is provided, documenting critical parameters such as assay, impurity profile, and solvent residues. We adhere to relevant quality management standards to support research requiring reliable and traceable biochemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation. For long-term storage, desiccate to prevent moisture uptake. Allow the sealed container to reach room temperature before opening to avoid condensation.

Specification

Item	Specification
Appearance	Off-white to light tan solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 95.0%
Water Content	≤ 1.0%
Solvent Residues	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.