Description

Calmidazolium Chloride is a potent and selective cell-permeable inhibitor of calmodulin, a key calcium-binding messenger protein. This compound is essential for researchers and developers in life sciences, providing a critical tool for modulating calcium signaling pathways and studying related physiological and pathological processes. It is primarily utilized in biochemical research, pharmaceutical development, and as a reference standard in analytical laboratories.

Application

• Biochemical Research: A fundamental tool for studying the role of calmodulin in cellular processes such as muscle contraction, neurotransmitter release, and cell cycle progression.
• Pharmaceutical R&D: Used in drug discovery programs targeting calmodulin-dependent enzymes (e.g., kinases, phosphatases) for potential therapeutic interventions in cardiovascular and neurological disorders.
• Signal Transduction Studies: Employed to dissect calcium/calmodulin-mediated signaling cascades in various cell types and model organisms.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in laboratory testing.
• Enzyme Inhibition Assays: Used in vitro to characterize the activity and specificity of calmodulin-dependent enzymes.

Basic Information

Product Name	Calmidazolium Chloride
CAS No.	57265-65-3
Molecular Formula	C₂₀H₂₂ClN₃O
Molecular Weight	355.86 g/mol
Synonyms	Calmidazolium; R 24571; 1-[Bis(4-chlorophenyl)methyl]-3-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazolium chloride; R24571; Calmidazolium Chloride (R24571); N-[2,4-Dichlorobenzyl]-N-[4-chlorophenyl]-1H-imidazole-1-ethanamine hydrochloride
EINECS	Contact for details

Quality Control

Our Calmidazolium Chloride is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling, to ensure it meets the high standards required for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with specified parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and desiccated to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.