Description

Desmethyl Mianserin is a key pharmaceutical intermediate and metabolite of the tetracyclic antidepressant Mianserin. This compound is of significant importance for research and development in neuropharmacology and analytical chemistry. It is primarily required by pharmaceutical manufacturers, contract research organizations (CROs), and analytical laboratories for use in drug metabolism and pharmacokinetic (DMPK) studies, reference standard preparation, and impurity profiling.

Application

• Pharmaceutical Intermediate: Critical for the synthesis and development of tetracyclic antidepressant compounds and related analogs.
• Metabolite Reference Standard: Used as an analytical standard in bioanalytical methods for quantifying Desmethyl Mianserin levels in biological matrices during clinical and preclinical studies.
• Impurity Standard: Essential for quality control in Mianserin API manufacturing, ensuring compliance with pharmacopeial limits for related substances.
• Pharmacological Research: Employed in in-vitro and in-vivo studies to investigate the pharmacological activity and metabolic pathways of Mianserin.
• Diagnostic Development: Potential use in the development of diagnostic assays for therapeutic drug monitoring (TDM).

Basic Information

Product Name	Desmethyl Mianserin
CAS No.	57257-81-5
Molecular Formula	C₁₇H₁₈N₂
Molecular Weight	250.34 g/mol
Synonyms	1,2,3,4,10,14b-Hexahydro-2-methyldibenzo[c,f]pyrazino[1,2-a]azepine; Nor-Mianserin; Demethylmianserin; 6H-Benzo[c][1]benzazepino[1,2-e]pyrazine, 1,2,3,4,10,14b-hexahydro-2-methyl-; Mianserin Impurity B; Mianserin Metabolite
EINECS	Contact for details

Quality Control

Our Desmethyl Mianserin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling via advanced techniques like HPLC and GC-MS, to ensure it meets the stringent requirements for pharmaceutical research and reference standard applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with specified standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.