Description

Maytansine, O3-Acetyl-O3-De2-(Acetylmethylamino)-1-Oxopropyl- is a highly potent cytotoxic agent and a key synthetic derivative in the maytansinoid class of compounds. Its primary value lies in its role as a critical payload for the development of Antibody-Drug Conjugates (ADCs), a revolutionary class of targeted cancer therapeutics. This compound is essential for pharmaceutical R&D teams and biotech companies focused on oncology, enabling the creation of next-generation treatments that deliver potent cell-killing agents directly to tumor cells while minimizing systemic toxicity.

Application

• Antibody-Drug Conjugate (ADC) Payload: Serves as the cytotoxic warhead conjugated to monoclonal antibodies for targeted cancer therapy.
• Oncology Research: Used as a reference standard and active pharmaceutical ingredient (API) in preclinical and clinical research for novel anticancer agents.
• Bioconjugation Chemistry: A key intermediate for developing linker-payload systems with optimized stability and potency.
• Mechanistic Studies: Employed in biochemical assays to study microtubule inhibition and apoptosis induction in cancer cells.
• Process Development: Used in scaling up and optimizing the synthesis of ADC drug substances under cGMP conditions.

Basic Information

Product Name	Maytansine, O3-Acetyl-O3-De2-(Acetylmethylamino)-1-Oxopropyl-
CAS No.	57103-69-2
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	N2'-Deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine; DM1; mertansine; Maytansinoid DM1; Ansamitocin P-3 derivative; NSC 332598; Immunoconjugate payload DM1
EINECS	Contact for details

Quality Control

Our Maytansine derivative is manufactured and controlled to meet the exacting standards required for pharmaceutical development. Each batch undergoes comprehensive analytical testing, including HPLC for purity and related substances, to ensure identity, potency, and consistency. A detailed Certificate of Analysis (COA) is provided, documenting compliance with in-house specifications developed for ADC payload applications. We support development with regulatory starting material (RSM) documentation packages.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.