Description

U-46619 CAS NO 56985-40-1 is a stable synthetic analog of the thromboxane A2 (TXA2) prostanoid, widely recognized as a potent and selective thromboxane receptor (TP receptor) agonist. This compound is an indispensable pharmacological tool for studying vascular physiology, platelet aggregation, and the pathophysiology of cardiovascular diseases. It is primarily utilized by researchers and developers in the pharmaceutical, biotechnology, and life science sectors for in vitro and in vivo studies related to hemostasis, thrombosis, and receptor signaling pathways.

Application

• Pharmacological Research: Used as a standard TP receptor agonist to investigate receptor binding, signal transduction, and the role of thromboxane in disease models.
• Cardiovascular Studies: Essential for inducing and studying vasoconstriction, platelet aggregation, and the development of anti-thrombotic agents.
• Drug Discovery & Development: Serves as a key reference compound for screening and validating novel thromboxane synthase inhibitors or TP receptor antagonists.
• Biochemical Assays: Employed in cell-based assays and tissue bath experiments to study smooth muscle contraction and vascular tone.
• Academic Research: A critical reagent for university and institutional labs focusing on prostaglandin biology, inflammation, and vascular pharmacology.

Basic Information

Product Name	U-46619
CAS No.	56985-40-1
Molecular Formula	C₂₁H₃₂O₅
Molecular Weight	364.48 g/mol
Synonyms	9,11-Dideoxy-9α,11α-methanoepoxy Prostaglandin F2α; 9,11-Methanoepoxy Prostaglandin F2α; Thromboxane A2 Mimetic; U46619; U 46619; 15(S)-Hydroxy-9α,11α-(epoxymethano)prosta-5Z,13E-dien-1-oic Acid
EINECS	Contact for details

Quality Control

Our U-46619 is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere). Allow the vial to reach room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.