Description

Minoxidil Glucuronide is a key metabolite of the vasodilator and hair growth stimulant minoxidil. This compound is of significant interest in pharmaceutical research and development, particularly for studying the pharmacokinetics, metabolic pathways, and efficacy of minoxidil-based treatments. It serves as a critical reference standard and intermediate for analytical laboratories, pharmaceutical manufacturers, and research institutions focused on dermatology and cardiovascular drug development.

Application

• Pharmaceutical Reference Standard: Used as a high-purity certified reference material (CRM) for the quantitative and qualitative analysis of minoxidil and its metabolites in biological matrices.
• Drug Metabolism & Pharmacokinetics (DMPK) Studies: Essential for in vitro and in vivo studies to understand the absorption, distribution, metabolism, and excretion (ADME) profile of minoxidil.
• Analytical Method Development: Serves as a critical component in developing and validating HPLC, LC-MS, and other chromatographic methods for impurity profiling and assay determination.
• Bioequivalence & Clinical Research: Employed in clinical trials to monitor metabolite levels and establish bioequivalence for generic formulations of minoxidil products.
• Active Pharmaceutical Ingredient (API) Intermediate: Can be utilized in the synthesis and quality control of advanced minoxidil formulations.

Basic Information

Product Name	Minoxidil Glucuronide
CAS No.	56828-40-1
Molecular Formula	C₁₄H₂₃N₅O₈
Molecular Weight	389.37 g/mol
Synonyms	Minoxidil N-O-Glucuronide; 2,4-Diamino-6-piperidinopyrimidine 3-oxide glucuronide; Minoxidil Glucuronide Metabolite; U-10,958 Glucuronide; Minoxidil O-Glucuronide; 6-(1-Piperidinyl)-2,4-pyrimidinediamine 3-oxide glucuronide; Minoxidil Major Metabolite
EINECS	Contact for details

Quality Control

Our Minoxidil Glucuronide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR), purity assessment by HPLC, and control of related substances and residual solvents. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research and pharmaceutical industry standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider keeping the material at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.