Description

(14R)-Grayanotoxane-3β,5,6β,7α,10,14,16-Heptol is a highly oxygenated diterpenoid natural product, a key structural member of the grayanotoxin family. This compound is of significant interest for its role as a precise biochemical tool and a critical reference standard in toxicological and pharmacological research. It is primarily required by research institutions, pharmaceutical development labs, and analytical testing facilities engaged in the study of ion channel modulation, natural product chemistry, and the development of analytical methods.

Application

• Pharmacological Research: Serves as a critical reference standard and active agent in studies of voltage-gated sodium channel modulation and neurotoxicity mechanisms.
• Analytical Chemistry: Used as a high-purity certified reference material (CRM) for the calibration of equipment and validation of analytical methods (e.g., HPLC, LC-MS) in forensic and food safety labs.
• Natural Product Isolation & Synthesis: Acts as a key intermediate or target molecule in the total synthesis and structural elucidation of complex diterpenoids.
• Toxicology Studies: Employed in the development and validation of assays for detecting grayanotoxin poisoning, relevant to honey and food safety monitoring.
• Biochemical Tool Development: Utilized in the creation of specialized assay kits and probes for studying ion channel function and signal transduction pathways.
• Academic & Institutional Research: Fundamental research into plant defense chemicals, structure-activity relationships (SAR), and biodiversity.

Basic Information

Item	Details
Product Name	(14R)-Grayanotoxane-3β,5,6β,7α,10,14,16-Heptol
CAS No.	56663-60-6
Molecular Formula	C20H34O7
Molecular Weight	386.48 g/mol
Synonyms	Grayanotoxin III; Grayanotoxane-3,5,6,7,10,14,16-heptol, (3β,5β,6β,7α,14R)-; Grayanotane-3,5,6,7,10,14,16-heptol; 3β,5β,6β,7α,14R-Grayanotoxane-3,5,6,7,10,14,16-heptol; Acetylandromedol; Rhodojaponin III (partial); Andromedotoxin congener.
EINECS	Contact for details

Quality Control

Our (14R)-Grayanotoxane-3β,5,6β,7α,10,14,16-Heptol is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from multiple orthogonal techniques such as HPLC, NMR, and MS. Our quality commitment supports research requiring reliable and traceable reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.