Description

5-Hydroxy-L-Tryptophan Tris(Trimethylsilyl) Deriv. is a silylated derivative of the essential amino acid precursor 5-HTP, designed to enhance volatility and stability for advanced analytical and synthetic applications. This specialized reagent is critical for researchers and manufacturers requiring precise derivatization to enable accurate gas chromatographic analysis or to serve as a protected intermediate in complex organic syntheses. It is primarily utilized in pharmaceutical R&D, analytical chemistry laboratories, and fine chemical production for the development and quality control of neurochemical and pharmaceutical compounds.

Application

• GC-MS Analysis: Used as a derivatization agent for the sensitive detection and quantification of 5-Hydroxytryptophan (5-HTP) and related tryptophan metabolites in biological samples.
• Pharmaceutical Intermediate: Serves as a key protected synthetic building block in the multi-step synthesis of complex molecules, including potential neuroactive drugs and research compounds.
• Metabolomics Research: Enables precise profiling of tryptophan pathway metabolites in clinical and preclinical studies for biomarker discovery.
• Reference Standard: Acts as a high-purity analytical standard for method development and validation in quality control laboratories.
• Chemical Synthesis: Provides a reactive, silyl-protected intermediate for introducing the 5-HTP moiety into larger molecular architectures under controlled conditions.

Basic Information

Product Name	5-Hydroxy-L-Tryptophan Tris(Trimethylsilyl) Deriv.
CAS No.	56272-77-6
Molecular Formula	C20H39N2O3Si3
Molecular Weight	439.78 g/mol
Synonyms	5-HTP-TMS; L-5-Hydroxytryptophan tris(trimethylsilyl) derivative; 5-Hydroxy-L-tryptophan, tris(trimethylsilyl) ether; Tris(trimethylsilyl) 5-hydroxy-L-tryptophan; TMS-5-HTP; Nα,O5-Tris(trimethylsilyl)-5-hydroxy-L-tryptophan
EINECS	Contact for details

Quality Control

Every batch of 5-Hydroxy-L-Tryptophan Tris(Trimethylsilyl) Deriv. is manufactured and tested under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.